Abstract
Structure-property relationship based on fragment descriptors of molecular structure was used to assess the ability of phenol derivatives to induce apoptosis in L1210 leukemia cells in mice. Simple models that provide quite accurate estimates for the apoptic activity of various phenol compounds were suggested. Such models allow one to clearly interpret the contributions of structural elements of phenol derivatives and to predict how their apoptic activity will vary with structural modification.
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Benoit-Guyod, J.-L., Andre, C., Taillanolier, S., Rochat, J., and Boucherie, A., Ecotoxicol. Environ. Saf., 1984, vol. 8, no. 3, p. 227.
Cronin, M.T. and Schultz, T.W., Chemosphere, 1986, vol. 32, no. 8, p. 1453.
Jauregui, O., Moyano, E., and Calceran, M.T., J. Chro-matogr. A, 1998, vol. 823, nos. 1–2, p. 241.
Selassie, C.D., Shusterman, A.J., Kapur, S., Verma, R.P., Zhang, L., and Hansch, C., J. Chem. Soc., Perkin Trans. 2, 1999, p. 2729.
Lu, G.-H., Yuan, X., and Zhao, Y.-H., Chemosphere, 2001, vol. 44, no. 3, p. 437.
Wang, X., Dong, J., Wang, L., and Han, Sh., Chemosphere, 2001, vol. 44, no. 3, p. 447.
Ohlenbesch, G. and Frimmel, F.H., Chemosphere, 2001, vol. 45, no. 3, p. 323.
Liptak, M.D., Gross, K.C., Seybold, P.G., Feldgus, S., and Shields, G.C., J. Am. Chem. Soc., 2002, vol. 124, no. 22, p. 6421.
Selassie, C.D., Kapur, S., Verma, R.P., and Rosario, M., J. Med. Chem., 2005, vol. 138, no. 23, p. 7234.
Baraboi, V.A., Biologicheskoe deistvie rastitel’nyh fenol’nyh soedinenii (Biologic Action of Plant Phenolic Compounds), Kiev: Naukova Dumka, 1976.
Zaprometov, M.N., Fenol’nye soedineniya (Phenolic Compounds), Moscow: Nauka, 1993.
Li, B.H., Ma, X.-F., Wang, Y., and Tian, Y., J. Bio-chem. (Japan), 2005, vol. 138, no. 6, p. 679.
Veselova, B.V., Fedoreev, S.A., Vasilevskaya, N.A., Denisenko, V.A., and Gerasimenko, A.V., Khim.-Farm. Zh., 2007, vol. 41, no. 2, p. 29.
Golovanov, I.B., Zhenodarova, S.M., Ivanitskii, G.R., and Sedel’nikova, E.A., Dokl. Akad. Nauk, 2002, vol. 382, no. 5, p. 695.
Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2003, vol. 73, no. 10, p. 1696.
Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2003, vol. 73, no. 1, p. 90.
Golovanov, I.B. and Tsygankova, I.G., Zh. Obshch. Khim., 1999, vol. 69, no. 8, p. 1275.
Golovanov, I.B. and Tsygankova, I.G., Quant. Struct. Act. Relat., 2000, vol. 19, p. 554.
Peltason, L. and Bojorath, J., J. Med. Chem., 2007, vol. 50, no. 23, p. 5571.
Draper, N.R. and Smith, H., Applied Regression Analysis, New York: Wiley, 1981, vol. 2. Translated under the title Prikladnoi regressionnyi analiz, Moscow: Finansy i Statistika, 1987, vol. 2, p. 22.
Shao, J., J. Am. Stat. Assoc., 1993, vol. 88, p. 486.
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Original Russian Text © I.G. Tsygankova, S.M. Zhenodarova, 2008, published in Zhurnal Obshchei Khimii, 2008, Vol. 78, No. 9, pp. 1529–1535.
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Tsygankova, I.G., Zhenodarova, S.M. Structure-property relationship for description of apoptosis (programmed cell death) induction by phenol derivatives. Russ J Gen Chem 78, 1760–1766 (2008). https://doi.org/10.1134/S1070363208090181
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DOI: https://doi.org/10.1134/S1070363208090181