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Sulfanylamide-containing coordination compounds of 3d-elements with 2,4-pentanedione bis-thiosemicarbazone and bis-4-phenylthiosemicarbazone

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Abstract

Thiosemicarbazide and 4-phenylthiosemicarbazide react in ethanol with 2,4-pentanedione in the presence of manganese, cobalt, nickel, copper, and zinc acetates hydrates and streptamin (Sf1), sulfaethidole (Sf2), and sulfadimidine (Sf3) to form coordination compounds of the composition M(Sf1–3)(L1–2) · nH2O (M = Mn, Co, Ni, Cu, Zn; H2L1 is 2,4-pentanedione bis-thiosemicarbazone, H2L2 is 2,4-pentanedione bis-4-phenylthiosemicarbazone; n = 0–6). All the complexes synthesized are monomeric. Thiosemicarbazones (H2L1 and H2L2) behave as twice deprotonated S,N,N,S-tetradentate ligands, while sulfanylamides (Sf1–3) act as monodentate ones. Thermolysis of these substances proceeds through the stages of dehydration (65–95°C) and complete thermal decomposition (430–560°C). It is found that the complex [Cu(Sf2)(L1)] · 4H2O in the concentration 10−5 M inhibits the growth and fission of 100% cancer cells of the human myeloid leukemia (HL-60).

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Authors and Affiliations

  1. Moldova State University, ul. Mateevicha 60, Kishinev, 2009, Moldova

    A. P. Gulya, S. N. Spynu & V. I. Tsapkov

  2. CHUQ, Laval University, Laval, GIV4G2, Canada

    D. Poirer

Authors
  1. A. P. Gulya
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  2. S. N. Spynu
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  3. V. I. Tsapkov
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  4. D. Poirer
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Additional information

Original Russian Text © A.P. Gulya, S.N. Spynu, V.I. Tsapkov, D. Poirer, 2008, published in Zhurnal Obshchei Khimii, 2008, Vol. 78, No. 5, pp. 841–847.

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Gulya, A.P., Spynu, S.N., Tsapkov, V.I. et al. Sulfanylamide-containing coordination compounds of 3d-elements with 2,4-pentanedione bis-thiosemicarbazone and bis-4-phenylthiosemicarbazone. Russ J Gen Chem 78, 984–990 (2008). https://doi.org/10.1134/S1070363208050253

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  • DOI: https://doi.org/10.1134/S1070363208050253

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