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Synthesis, crystal structure, and antitumour activities of cobalt(II) complex based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine

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Abstract

A new cationic complex, [Co(Bpbp)2](ClO4)2 · DMF · H2O, was synthesized by treatment Co(ClO4)2 · 6H2O with 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine (Bpbp) in DMF solvent at room temperature. Its structure was characterized by element analysis, IR, and X-ray single crystal structure analyses (CIF file CCDC no. 970498). For complex, crystal system, triclinic, space group, \(P\bar \imath\), a = 11.585(13), b = 13.939(16), c = 19.236(2) \(\mathop {\AA}\limits^\prime\), α = 97.938(2)°, β = 102.814(2)°, γ = 90.556(2)°, V = 2861.1(6) Ǻ3, Z = 2. The Co2+ ion octahedral geometry is coordinated by six nitrogen atoms from two ligand (Bpbp). The antiproliferative activities of the complex were screened by MTT assay against HepG2, Huh7, Eca109 and Eca9706 cancer cell. The complex exhibits inhibition on Eca9706 and Eca109 cancer cell but no HepG2 and Huh7 cancer cell.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang, 524048, P.R. China

    G. B. Li, W. Y. Su, R. K. Pan, K. D. Liu & S. G. Liu

  2. Institute of Molecular Medicine, Medical School of Shenzhen University, Shenzhen, 518060, P.R. China

    S. X. Wang

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  1. G. B. Li
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  2. S. X. Wang
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  3. W. Y. Su
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  4. R. K. Pan
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  5. K. D. Liu
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  6. S. G. Liu
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Correspondence to S. G. Liu.

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Li, G.B., Wang, S.X., Su, W.Y. et al. Synthesis, crystal structure, and antitumour activities of cobalt(II) complex based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine. Russ J Coord Chem 40, 764–767 (2014). https://doi.org/10.1134/S1070328414100054

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  • DOI: https://doi.org/10.1134/S1070328414100054

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