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Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine

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Abstract

A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine (Va–Vj) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (III) with different substituted benzoic acids (IVa–IVj) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their in vitro antifungal activities against C. albicans and A. niger by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary Mycobacterium smegmatis mc2 155. The compounds (Vg) and (Vh) exhibits promising activity with MICs 91 and 109 μg/mL respectively.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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ACKNOWLEDGMENTS

The authors are thankful to Principal, Maulana Azad College, Aurangabad, and Principal, Swami Vivekanand College Mantha for providing research facilities. We also thank SAIF Punjab University, Chandigarh and SAIF Shillong for providing the spectral and analytical data.

Funding

This work was supported by regular institutional funding, and no additional grants were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Swami Vivekanand Senior College Mantha, 431504, Maharashtra, India

    B. K. Dhotre

  2. Department of Chemistry, Maulana Azad College Aurangabad, 431001, Maharashtra, India

    S. V. Raut, M. Farooqui, S. B. Jadhav & A. Pathan

Authors
  1. B. K. Dhotre
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  2. S. V. Raut
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  3. M. Farooqui
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  4. S. B. Jadhav
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  5. A. Pathan
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Contributions

The authors BKD and SVR designed the experiment and synthesized the compound; the authors BKD and SBJ carried out the antitubercular activity and antifungal activity of synthesized compound. The author AP contributed to manuscript preparation. The author SVR participated in data processing. The authors MF and AP carried out studies using IR, 1H NMR, and Mass spectroscopy. All authors participated in the discussions.

Corresponding author

Correspondence to B. K. Dhotre.

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This article does not contain any studies involving patients or animals as test objects. Informed consent was not required for this article. No conflict of interest was declared by the authors.

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Dhotre, B.K., Raut, S.V., Farooqui, M. et al. Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine. Russ J Bioorg Chem 49 (Suppl 1), S171–S178 (2023). https://doi.org/10.1134/S1068162023080149

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