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Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif

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Abstract

Galodif (1-((3-chlorophenyl)(phenyl)methyl)urea) is an anticonvulsant that can also be used in the treatment of alcohol addiction. However, galodif is practically insoluble in water, which significantly limits its use for therapeutic purposes. It is known that good water solubility improves the bioavailability of pharmaceuticals, which ensures a reduction in the applied dose and a decrease in possible side and undesirable effects of the drug. In this paper, a method of solubilization of galodif in water using a self-emulsifying drug delivery system (SEDDS) is proposed. The developed pharmacological compositions consist of ingredients that are available and widely used in pharmacy. The use of gelatin capsules with developed SEDDS increases the solubility of galodif in water more than 80% compared to its tablet form. An increase in the dissolution rate of the drug with SEDDS in the intestinal environment has been shown.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was done within the framework of the state assignment of the Ministry of science and higher education of the Russian Federation (Science no. FSWW-2023-0008).

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Authors and Affiliations

  1. The Kizhner Research Center, National Research Tomsk Polytechnic University, 634050, Tomsk, Russia

    V. U. Kuksenok, V. V. Shtrykova & V. D. Filimonov

  2. Mental Health Research Institute, Tomsk National Research Medical Center, RAS, 634014, Tomsk, Russia

    T. V. Shushpanova & N. A. Bokhan

  3. Siberian State Medical University, 634050, Tomsk, Russia

    N. A. Bokhan

  4. University of Chemistry and Technology Prague, 16628, Prague, Czech Republic

    L. Seilerová, B. Kratohvil & V. Sieberová

Authors
  1. V. U. Kuksenok
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  2. V. V. Shtrykova
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  3. V. D. Filimonov
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  4. T. V. Shushpanova
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  5. N. A. Bokhan
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  6. L. Seilerová
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  7. B. Kratohvil
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  8. V. Sieberová
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All authors participated in writing the text of the article and made an equal contribution.

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Correspondence to V. U. Kuksenok.

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This article does not contain any studies involving patients or animals as test objects. Informed consent was not required for this article. No conflict of interest was declared by the authors.

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Kuksenok, V.U., Shtrykova, V.V., Filimonov, V.D. et al. Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif. Russ J Bioorg Chem 49 (Suppl 1), S8–S12 (2023). https://doi.org/10.1134/S1068162023080022

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