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Study on Modification of Paclitaxel and Its Antitumor Preparation

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Abstract

Paclitaxel (PTX) was discovered more than 50 years ago in 1968. The drug, known as the first herbal-derived chemotherapeutic drug approved, works by inhibiting the cell cycle. However, due to its poor water solubility and non-selective toxicity, severe side effects often occur accompanied with the clinical application of drugs. How to enhance the efficacy of paclitaxel has become an urgent problem to researchers. Aiming to provide new ideas for structural modification and drug delivery system development, structural modification of paclitaxel, including the introduction of small molecular fragments or soluble polymers at the C-2' and C-7 sites and nanocarrier-based new generation PTX drugs Abraxane and Lipusu are discussed in this review.

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Funding

All authors acknowledge the financial support from the Fundamental Research Funds for the Central Universities (no. 2572021DJ07), and the support from the 111 Project (B20088), and the National Students’ Platform for Innovation and Entrepreneurship Training Program (no. 202110225168), and Postdoctoral Foundation of Heilongjiang Province.

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 150040, Harbin, Heilongjiang, China

    Wenhao Zhou, Hongshang Hu & Ting Wang

  2. Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-Based Active Substances, 150040, Harbin, China

    Wenhao Zhou, Hongshang Hu & Ting Wang

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Wenhao Zhou, Hu, H. & Wang, T. Study on Modification of Paclitaxel and Its Antitumor Preparation. Russ J Bioorg Chem 49, 288–297 (2023). https://doi.org/10.1134/S1068162023020255

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