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The Anti-Inflammatory Effect of Peptide LKEKK

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Abstract

The review summarizes and systematizes data on the anti-inflammatory effect of the synthetic peptide LKEKK in vitro and in vivo. Based on the analysis, it was concluded that this peptide has a significant therapeutic potential as an anti-inflammatory drug in Crohn’s disease, various forms of colitis and contact dermatitis.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, 142290, Pushchino, Russia

    E. V. Navolotskaya, D. V. Zinchenko & A. N. Murashev

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  1. E. V. Navolotskaya
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  2. D. V. Zinchenko
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Correspondence to E. V. Navolotskaya.

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Additional information

Abbreviations: CT-B, B-subunit of cholera toxin; cGMP, cyclic guanosine-3',5'-monophosphate; DSS, dextran sodium sulfate; IFN, interferon; iNOS, inducible NO synthase; LPS, lipopolysaccharide; ODQ-1H-[1,2,4]oxadiazol[4,3-α]quinoxalin-1-one; pGC, membrane-bound guanylate cyclase; sGC, soluble guanylate cyclase; TM-α1, thymosin-α1; TRA, 12-O-tetradecanoylphorbol-13-acetate.

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Navolotskaya, E.V., Zinchenko, D.V. & Murashev, A.N. The Anti-Inflammatory Effect of Peptide LKEKK. Russ J Bioorg Chem 49, 35–40 (2023). https://doi.org/10.1134/S106816202301020X

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