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Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent

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Abstract

A series of phenyl-5-(2,3,5,6-tetrafluoro-phenyl)-[1,3,4]-oxadiazole were prepared from 2,3,5,6-tetrafluoro-benzoic acid hydrazide by treatment with various substituted benzoic acid in the presence of phosphorus oxychloride using conventional as well as microwave-assisted methods. Evaluation of antibacterial activity of synthesized compound against S. aures, S. pyogenes, S. typhi and Pseudomonas species and antifungal activity against C. albicans and A. niger has been carried out. The compounds (Vb) and (Ve) showed significant activity against both bacteria and fungi. Some of the compounds has shown moderate activity against both the bacteria and fungi. The molecular docking studies also done which support the antimicrobial activity exhibited high inhibition constant and binding energy. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR and mass spectra.

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ACKNOWLEDGMENTS

We are thankful to Principal, Maulana Azad College, Aurangabad, and Principal, Swami Vivekanand College Mantha for providing research facilities. We also thank SAIF Punjab University, Chandigarh and SAIF Shillong for providing the spectral and analytical data.

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Authors and Affiliations

  1. Department of Chemistry, Swami Vivekanand Senior College, Mantha, Maharashtra, India

    B. K. Dhotre

  2. Navin Research and Innovation Centre, NFIL, Surat, Gujarat, India

    M. A. Patharia

  3. Department of Chemistry, JES College, Jalna, Maharashtra, India

    A. U. Khandebharad

  4. Department of Chemistry, Maulana Azad College, Aurangabad, Maharashtra, India

    S. V. Raut & M. A. Pathan

Authors
  1. B. K. Dhotre
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  2. M. A. Patharia
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  3. A. U. Khandebharad
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  5. M. A. Pathan
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Correspondence to B. K. Dhotre.

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Dhotre, B.K., Patharia, M.A., Khandebharad, A.U. et al. Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent. Russ J Bioorg Chem 46, 1110–1116 (2020). https://doi.org/10.1134/S1068162020060059

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