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Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

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Abstract

In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for α-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good α-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using \({\text{ABT}}{{{\text{S}}}^{{\centerdot {\text{ + }}}}}\) and \({\text{DPP}}{{{\text{H}}}^{\centerdot }}\) methods. The results showed that all compounds exhibited moderated to high scavenging activity.

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REFERENCES

  1. Rahim, F., Ullah, H., Javid, M.T., Wadood, A., Taha, M., Ashraf, M., Shukat, A., Junaid, M., Hussain, S., Rehman, W., Mehmood, R., Sajid, M., Khan, M.N., and Khan, K.M., Bioorg. Chem., 2015, vol. 65, pp. 15–21.

    Article  Google Scholar 

  2. Wang, G., He, D., Li, X., Li, J., and Peng, Z., Bioorg. Chem., 2016, vol. 65, pp. 167–74.

    Article  CAS  Google Scholar 

  3. Özil, M., Parlak, C., and Baltaş, N., Bioorg. Chem., 2018, vol. 76, pp. 468–77.

    Article  Google Scholar 

  4. Escandón-Rivera, S., González-Andrade, M., Bye, R., Linares, E., Navarrete, A., and Mata, R., J. Nat. Prod., 2012, vol. 75, pp. 968–974.

    Article  Google Scholar 

  5. Chaudhury, A., Duvoor, C., Reddy Dendi, V.S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., Patil, N., Musham, C. K., Lohani, G.P., and Mirza, W., Front. Endocrinol. (Lausanne), 2017, vol. 8, pp, 1–12.

  6. Menteşe, E., Karaali, N., Akyüz, G., Yılmaz, F., Ülker, S., and Kahveci, B., Chem. Heterocycl. Compd., 2017, vol. 52, pp. 1017–1024.

    Article  Google Scholar 

  7. Yilmaz, F., Menteşe, E., and Baltaş, N., Lett. Drug. Des. Discov., 2017, vol. 14, pp. 201–208.

    Article  Google Scholar 

  8. Özyürek, M., Bektaşoǧlu, B., Güçlü, K., and Apak, R., Anal. Chim. Acta., 2009, vol. 636, pp. 42–50.

    Article  Google Scholar 

  9. Bellina, F. and Rossi, R., Tetrahedron, 2006, vol. 62, pp. 7213–7256.

    Article  CAS  Google Scholar 

  10. Obniska, J., Kaminski, K., and Chlebek, I., Acta Pol. Pharm.-Drug Res., 2009, vol. 66, pp. 663–669.

    CAS  Google Scholar 

  11. Musa, M., Cooperwood, J., and Khan, M.O., Curr. Med. Chem., 2008, vol. 15, pp. 2664–2679.

    Article  CAS  Google Scholar 

  12. Borges Bubols, G., da Rocha Vianna, D., Medina-Remon, A., von Poser, G., Maria Lamuela-Raventos, R., Lucia Eifler-Lima, V., and Garcia, S.C., Mini-Reviews Med. Chem., 2013, vol. 13, pp. 318–334.

    Google Scholar 

  13. Montagner, C., De Souza, S.M., Groposo, C., Delle Monache, F., Smânia, E.F.A., and Smânia, A., Zeitschrift fur Naturforsch—Sect. C,J. Biosci., 2008, vol. 63, pp. 21–28.

    CAS  Google Scholar 

  14. Bansal, Y., Sethi, P., and Bansal, G., Med. Chem. Res., 2013, vol. 22, pp. 3049–3060.

    Article  CAS  Google Scholar 

  15. Kaur, M., Kohli, S., Sandhu, S., Bansal, Y., and Bansal, G., Anticancer Agents Med. Chem., 2015, vol. 15, pp. 1032–1048.

    Article  CAS  Google Scholar 

  16. Bekircan, O., Ülker, S., and Menteşe, E., J. Enzyme Inhib. Med. Chem., 2015, vol. 30, pp. 1002–1009.

    Article  CAS  Google Scholar 

  17. Salat, K., Moniczewski, A., and Librowski, T., Mini Rev. Med. Chem., 2013, vol. 13, pp. 335–352.

    CAS  PubMed  Google Scholar 

  18. Fhid, O.R., Zeglam, T.H., Saad, S.E., Shlaka, M., and Dao, M., World J. Pharm. Pharm. Sci., 2015, vol. 4, pp. 24–34.

    CAS  Google Scholar 

  19. Kahveci, B., Yilmaz, F., Menteşe, E., and Ülker, S., Chem. Heterocycl. Compd., 2015, vol. 51, pp. 447–456.

    Article  CAS  Google Scholar 

  20. Kahveci, B., Yılmaz, F., Menteşe, E., and Ülker, S., Arch. Pharm. (Weinheim), 2017, vol. 350, pp. 1–9.

    Article  Google Scholar 

  21. Bardajee, G.R., Jafarpour, F., and Afsari, H.S., Cent. Eur. J. Chem., 2010, vol. 8, pp. 370–374.

    CAS  Google Scholar 

  22. Creaven, B.S., Egan, D.A., Kavanagh, K., McCann, M., Noble, A., Thati, B., and Waslsh, M., Inorganica Chim. Acta, 2006, vol. 359, pp. 3976–3984.

    Article  CAS  Google Scholar 

  23. Danko, M., Szabo, E., and Hrdlovic, P., Dye Pigment, 2011, vol. 90, pp. 129–138.

    Article  CAS  Google Scholar 

  24. Shults, E.E., Bondarenko, S.P., Shakirov, M.M., Bagryanskaya, I.Y., and Tolstikov, G.A., Russ. J. Org. Chem., 2010, vol. 46, pp. 1709–1718.

    Article  CAS  Google Scholar 

  25. Bigi, F., Chesini, L., Maggi, R., and Sartori, G., J. Org. Chem., 1999, vol. 64, pp. 1033–1035.

    Article  CAS  Google Scholar 

  26. Kostova, I., Curr. Hiv. Res., 2006, vol. 4, pp. 347–363.

    Article  CAS  Google Scholar 

  27. Menteşe, E., Yilmaz, F., Baltaş, N., Bekircan, O., and Kahveci, B., J. Enzyme Inhib. Med. Chem., 2015, vol. 30, pp. 435–441.

    Article  Google Scholar 

  28. Özil, M., Emirik, M., Beldüz, A., and Ülker, S., Bioorganic Med. Chem., 2016, vol. 24, pp. 5103–5114.

    Article  Google Scholar 

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Authors and Affiliations

  1. Vocational School of Technical Studies, Department of Chemistry and Chemical Processing Technology, Recep Tayyip Erdogan University, 53100, Rize, Turkey

    Fatih Yılmaz

  2. Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University, 53100, Rize, Turkey

    Emre Menteşe & Nimet Baltaş

Authors
  1. Fatih Yılmaz
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  2. Emre Menteşe
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  3. Nimet Baltaş
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Correspondence to Emre Menteşe.

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Authors declare that they have no conflicts of interests.

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Corresponding author: e-mail: emre.mentese@erdogan.edu.tr.

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Fatih Yılmaz, Menteşe, E. & Baltaş, N. Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules. Russ J Bioorg Chem 45, 575–584 (2019). https://doi.org/10.1134/S1068162019060402

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  • DOI: https://doi.org/10.1134/S1068162019060402

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