Russian Journal of Bioorganic Chemistry

, Volume 43, Issue 3, pp 323–327 | Cite as

Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations

  • J. Q. Luo
  • F. Jiang
  • W. Q. Song
  • W. Z. FangEmail author
  • Q. LuEmail author


A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.


paricalcitol vitamin D2 microbial transformation chemical synthesis 


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© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.Department of Сhemistry, School of Life Science and EngineeringSouthwest Jiaotong UniversityChengduChina

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