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Synthesis and pharmacological activity of N-hetaryl-3(5)-nitropyridines

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Abstract

Previously undescribed 2-, 4or 6-substituted hetaryl-3(5)-nitropyridines were synthesized by the interaction of a number of chlorosubstituted 3(5)-nitropyridines with some diazoles or 3-chloropyridazin-6one. In addition, pyrazolyl-3-nitropyridines were prepared by both the above method and cyclization of hydrazinopyridines, which, in turn, were synthesized by the treatment of chlorosubstituted 3-nitropyridines with hydrazine. It has been shown that these compounds have a moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli) and a strong protistocidal effect on protozoa species Colpoda steinii surpassing in this respect clinically used reference drugs.

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Authors and Affiliations

  1. Institute of Organic and Physical Chemistry, South Federal University, pr. Stachky 194/2, Rostov-on-Don, 344090, Russia

    L. N. Divaeva & A. S. Morkovnik

  2. North-Caucasian Zonal Scientific Research Veterinary Institute, Novocherkassk, Russia

    A. A. Zubenko, L. N. Fetisov & A. N. Bodryakov

  3. Don State Agrarian University, Novocherkassk, Russia

    A. I. Klimenko

Authors
  1. A. I. Klimenko
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  2. L. N. Divaeva
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  3. A. A. Zubenko
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  4. A. S. Morkovnik
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  5. L. N. Fetisov
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  6. A. N. Bodryakov
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Correspondence to L. N. Divaeva.

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Original Russian Text © A.I. Klimenko, L.N. Divaeva, A.A. Zubenko, A.S. Morkovnik, L.N. Fetisov, A.N. Bodryakov, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 4, pp. 454–461.

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Klimenko, A.I., Divaeva, L.N., Zubenko, A.A. et al. Synthesis and pharmacological activity of N-hetaryl-3(5)-nitropyridines. Russ J Bioorg Chem 41, 402–408 (2015). https://doi.org/10.1134/S1068162015030048

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  • DOI: https://doi.org/10.1134/S1068162015030048

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