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In vitro binding of human serum low-density lipoproteins by sulfated pectin derivatives

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Abstract

It was shown that sulfated pectin derivatives bind human serum low-density lipoproteins (LDLs) in vitro to a greater extent than native pectins. At the same time, the number of sulfate groups and the molecular weight of sulfated derivatives were crucial factors. The sulfated pectin derivatives with molecular weights more than 200 kDa containing 45 wt % sulfate groups had the greatest ability to bind LDLs, while the sulfated derivatives with molecular weights lower than 50 kDa containing 5% sulfate groups exhibited the lowest activity.

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Abbreviations

BC:

Bergenia crassifolia pectin

BCS1, BCS2, and BCS3:

sulfated derivatives of BC

LM:

Lemna minor pectin

LMS1, LMS2, and LMS3:

sulfated derivatives of LM

PN:

Potamogeton natans pectin

PNS1, PNS2, and PNS3:

sulfated derivatives of PN

HDL:

high-density lipoprotein

LDL:

low-density lipoprotein

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Authors and Affiliations

  1. Institute of Physiology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 50, Syktyvkar, 167982, Russia

    F. V. Vityazev, N. M. Paderin & V. V. Golovchenko

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  1. F. V. Vityazev
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  2. N. M. Paderin
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  3. V. V. Golovchenko
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Correspondence to F. V. Vityazev.

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Original Russian Text © F.V. Vityazev, N.M. Paderin, V.V. Golovchenko, 2012, published in Bioorganicheskaya Khimiya, 2012, Vol. 38, No. 3, pp. 365–369.

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Vityazev, F.V., Paderin, N.M. & Golovchenko, V.V. In vitro binding of human serum low-density lipoproteins by sulfated pectin derivatives. Russ J Bioorg Chem 38, 319–323 (2012). https://doi.org/10.1134/S1068162012030156

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  • DOI: https://doi.org/10.1134/S1068162012030156

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