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Effect of Strontium and Calcium Impurities on Productivity of 82Sr/82Rb Medical Generator

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Radiochemistry Aims and scope

An Erratum to this article was published on 01 December 2023

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Abstract

The 82Sr/82Rb generator is used to produce a radiopharmaceutical rubidium-82 chloride in saline solution for PET imaging. In this work, we studied the effect of the amount of stable strontium and calcium delivered to the sorbent (on the basis of hydrated tin dioxide) on the maximum volume of radiopharmaceutical solution that can be obtained from the generator. Sr and Ca may be delivered to the sorbent from the initial solution of strontium-82 chloride or from the eluent (0.9% NaCl) during medical application of the generator. It is shown that this volume depends on the value CSr + 0.11CCa, where CSr and CCa are molar concentrations of the elements in 1 g of the sorbent. The obtained results make it possible to increase significantly the productivity and reliability of the used generators.

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REFERENCES

  1. Chudakov, V.M., Zhuikov, B.L., Ermolaev, S.V., Kokhanyuk, V.M., Mostova, M.I., Zaitsev, V.V., Shatik, S.V., Kostenikov, N.A., Ryzhkova, D.V., and Tyutin, L.A., Radiochemistry, 2014, vol. 56, no. 5, p. 535

    Article  CAS  Google Scholar 

  2. CARDIOGEN-82 ® Rubidium Rb 82. 43-8200H. Revised October 2020. https://www.bracco.com/us-en-2020-11-24-spc-cardiogen-82.

  3. RUBY-FILL® (Rubidium Rb-82 Generators) and Elution System. https://www.draximage.com/products/USA/ruby-fill-(rubidium-rb-82-generator)-and-elution-system.

  4. Zhuikov, B.L., Chudakov, V.M., and Kokhanyuk, V.M. Patent RF no. 2546731. 2013.

  5. Granov, A.M., Tyutin, L.A., Tlostanova, M.S. Ryzh-kova, D.V., Kostenikov, N.A., Khodzhibekova, M.M., Stanzhevskii, A.A., Pishchik, V.G., Avetisyan, A.O., Shtukovskii, O.A., Mostova, M.I., Zaitsev, V.V., Shatik, S.V., and Zhuikov, B.L., Meditsinskaya Vizualizatsiya, 2013, no. 2, p. 75

    Google Scholar 

  6. Kostenikov, N.A., Zhuikov, B.L., Chudakov, V.M., Ilyushchenko, Yu.R., Shatik, S.V., Zaitsev, V.V., Sysoev, D.S., Panfilenko, A.F., and Stanzhevskii, A.A., Luchevaya diagnostika i terapiya (Radiation Diagnostics and Therapy), 2017, no. 3(8), p. 5. https://doi.org/10.22328/2079-5343-2017-3-5-13

    Article  Google Scholar 

  7. Kostenikov, N.A.; Zhuikov, B.L., Chudakov, V.M., Ilyushenko Yu.R., Shatik, S.V., Zaitsev, V.V., Sisoev, D.S., and Stanzhevskiy, A.A., Brain Behav., 2019, vol. 9, p. 316. https://doi.org/10.1002/brb3.1212

    Article  Google Scholar 

  8. NAOGEN PHARMA. RUBIGEN®. https://www.naogen-pharma.com/en/our-products/.

  9. Chatal, J-F., Rouzet, F., Haddad, F., Bourdeau, C., Mathieu, C., and Le Guludec, D., Front. Med., 2015, vol. 2, p. 65. https://doi.org/10.3389/fmed.2015.00065

    Article  Google Scholar 

  10. Brooks, D.J., Beaney, R.P, Lammertsma, A.A., Leenders, K.L., Horlock, P.L., Kensett, M.J., Marshall, J., Thomas, D.G., and Jones, T., J. Cereb. Blood Flow Metab., 1984, no. 4, p. 535. https://doi.org/10.1038/jcbfm.1984.78

    Article  Google Scholar 

  11. Jochumsen, M.R., Tolbod, L.P., Pedersen, B.G., Nielsen, M.M., Hoyer, S., Flokaer, J., Borre, M., Bouchelouche, K., and Sorensen, J., J. Nucl. Med., 2019, vol. 60, p. 1059. https://doi.org/10.2967/jnumed.118.219188

    Article  CAS  PubMed  Google Scholar 

  12. CardioGen-82® (Rubidium Rb82 Generator). Bracco Imaging. https://cardiogen.com/cardiac-pet/.

  13. Suleiman, O.H., FDA Update: The Strontium/Rubidium Generator., U.S. Food and Drug Administration. Nuclear Regulatory Commission’s Advisory Committee on Medical Use of Isotopes, April 16–17, 2012. https://www.nrc.gov/docs/ML1210/ML12101A274.pdf.

  14. Ahmadi, A., Klein, R., Lewin, H.C., Beanlands, R.S.B., and deKemp, R.S.B., J. Nucl. Cardiol., 2020, vol. 27, no. 5, pp. 1728–1738. https://doi.org/10.1007/s12350-020-02200-6

    Article  PubMed  PubMed Central  Google Scholar 

  15. Chudakov, V.M., Shatik, S.V., Zhuikov, B.L., Patent RU 2765983 C1. 30.03.2021.

  16. Zhuikov, B.L., Kokhanyuk, V.M., Konyakhin, N.A., and Vincent, J., Nucl. Instrum. Meth. Phys. Res. A, 1999, vol. 438, p. 173

    Article  CAS  ADS  Google Scholar 

  17. Zhuikov,, B.L., Kokhanyuk,, V.M., Gluschenko, V.N., Pilipenko, S.I., Kavkhuta, G.A., Vincent, J., and Cackette, M., Radiokhimiya, 1994, vol. 36, no. 6, p. 548

    Google Scholar 

  18. Phillips, D.R., Peterson, E.J., Taylor, W.A., Jamriska, D.J., Hamilton, V.T., Kitten, J.J., Valdez, F.O., Salazar, L.L., Pitt, L.R., Heaton, R.C., Kolsky, K.L., and Mausneret, L.F., Radiochim. Acta, 2000, vol. 88, pp. 149. https://doi.org/10.1524/ract.2000.88.3-4.149

    Article  CAS  Google Scholar 

  19. Zhuikov, B.L., Kokhanyuk, V.M., and Vinsent, D.C., Radiokhimiya, 2008, vol. 50, no. 2, p. 162

    Google Scholar 

  20. Zhuikov, B.L., Ermolaev, S.V., Kokhanyuk, V.M., Patent RU 2356113. 2008.

  21. Registratsionnoe udostoverenie na meditsinskoe izdelie no. RZN 2014/1669 ot 01.07.2014 g. Generator rubidiya-82 GR-01 (GR-02) po TU 9452-025-05627150-2012 (Registration Certificate for Medical Device no. RZN 2014/1669 dated July 1, 2014. Rubidium-82 generator GR-01 (GR-02) according to TU 9452-025-05627150-2012).

  22. Gosudarstvennaya farmakopeya Rossiiskoi Federatsii XIV izdaniya. Farmsubstantsii mineral’nogo proiskhozhdeniya. FS.2.2.0014. Natriya khlorid (State Pharmacopoeia of the Russian Federation XIV edition. Pharmaceutical substances of mineral origin. FS.2.2.0014. Sodium chloride).

  23. Suetina, A.K., Belokonova, N.V., and Voronina, A.V., Aktual’nye problemy razvitiya tekhnicheskikh nauk: sbornik statei uchastnikov XXIV Oblastnogo konkursa nauchno-issledovatel’skikh rabot “Nauchnyi Olimp” po napravleniyu “Tekhnicheskie nauki” (Current Problems in the Development of Technical Sciences: a Collection of Articles by Participants of the XXIV Regional Research Competition “Scientific Olympus” in the direction of “Technical Sciences”), Yekaterinburg: Ural’skii federal’nyi universitet, 2021. http://hdl.handle.net/10995/106026.

    Google Scholar 

  24. Strontium-82 Radiochemical Strontium Chloride Solution. Sr-82 Fact Sheet. MDS Nordion, Canada. NM01 10. Can. Rev. 05|04. http://.

  25. Strontium-82. Product Catalog. National Isotope Development Center, Oak Ridge National Laboratory, 1996–2013.

  26. Sodium Chloride (USP, BP, Ph, Eur.), PanReac AppliChem ITW Reagents. Code 141659. CAS 7647-14-5. https://itwreagents.com/italy/en/product/sodium-chloride-usp-bp-ph-eur-jp-pure-pharma-grade/141659.

  27. Mashkovskii, M.D., Lekarstvennye sredstva (Medicines), Moscow: Novaya volna, 2005.

    Google Scholar 

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ACKNOWLEDGMENTS

The authors express their gratitude to S.V. Ermolaev and other employees of the Laboratory of Radioisotope Complex INR RAS for valuable comments and assistance in conducting experiments, V.K. Karandashev (ASIC IPTM RAS) for performing the analysis of the initial solutions.

The study was carried out using the equipment of the Center for Collective Use of the Institute for Nuclear Research of the Russian Academy of Sciences (agreement with the Ministry of Education and Science No. 14.621.21.0014, unique work identifier RFMEF162117X0014).

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Institute for Nuclear Research, Russian Academy of Sciences, 117312, Moscow, Russia

    V. M. Chudakov & B. L. Zhuikov

  2. Russian Scientific Center for Radiology and Surgical Technology, 197758, St. Petersburg, Russia

    S. V. Shatik

Authors
  1. V. M. Chudakov
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  2. S. V. Shatik
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  3. B. L. Zhuikov
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Correspondence to V. M. Chudakov.

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Translated from Radiokhimiya, No. 5, pp. 447–457, October, 2023 https://doi.org/10.31857/S0033831123050075

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Chudakov, V.M., Shatik, S.V. & Zhuikov, B.L. Effect of Strontium and Calcium Impurities on Productivity of 82Sr/82Rb Medical Generator. Radiochemistry 65, 567–577 (2023). https://doi.org/10.1134/S1066362223050077

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