Skip to main content
SpringerLink
Log in

Terbium Isotopes in Nuclear Medicine: Production, Recovery, and Application

  • Published:
Radiochemistry Aims and scope

Abstract

Terbium has four short-lived radioactive isotopes with mass numbers 149, 152, 155, and 161, which are promising for use in various fields of nuclear medicine, but this topic is currently at the research stage. Nowadays, the conditions for the production and recovery of these carrier free isotopes from irradiated targets, and preclinical and clinical trials of radiopharmaceuticals based on these nuclides are being actively studied. The results of the relevant reports are systematized in the presented review, which makes it possible to determine the main achievements and directions of research on terbium isotopes to date.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.

Similar content being viewed by others

REFERENCES

  1. Blower, P.J., Dalton Trans., 2015, vol. 44, no. 11, pp. 4819–4844.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Müller, C., Reber, J., Haller, S., Dorrer, H., Köster, U., Johnston, K., Zhernosekov, K., Türler, A., and Schibliet, R., Pharmaceuticals, 2014, vol. 7, no. 3, pp. 353–365.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Uusijärvi, H., Bernhardt, P., Rosch, F., Helmut, R., Maecke, H.R., and Forssell-Aronsson, E., J. Nucl. Med., 2006, vol. 47, no. 5, pp. 807–814.

    PubMed  Google Scholar 

  4. Müller, C., Domnanich, K.A., Umbricht, C.A., and van der Meulen, N.P., Br. J. Radiol., 2018, vol. 91, no. 1091, ID 20180074.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Talip, Z., Favaretto, C, Geistlich, S., and van der Meulen, N.P., Molecules, 2020, vol. 25, no. 4, p. 966.

    Article  CAS  PubMed Central  Google Scholar 

  6. Franz, E.M. and Friedlander, G., Nucl. Phys., 1966, vol. 76, pp. 123–128.

    Article  CAS  Google Scholar 

  7. Charalambus, S., Nucl. Phys., Sect. A., 1967, vol. 94, no. 1, pp. 26–32.

    Article  CAS  Google Scholar 

  8. Heydegger, H.R., Nucl. Phys., Sect. A., 1972, vol. 196, pp. 156–160.

    Article  CAS  Google Scholar 

  9. Stehney, A.F. and Steinberg, E.P., Nucl. Instrum. Meth., 1968, vol. 59, no. 1, pp. 102–108.

    Article  CAS  Google Scholar 

  10. Steinberg, E.P., Stehney, A.F., Stearns, C., and Spaletto, I., Nucl. Phys. A, 1968, vol. 113, no. 2, pp. 265–271.

    Article  CAS  Google Scholar 

  11. Köster, U., Fedoseyev, V.N., Andreyev, A.N., Bergmann, U.C., Catherall, R., Cederkäll, J., Dietrich, M., De Witte, H., Fedorov, D.V., Fraile, L., Franchoo, S., Fynbo, H., Georg, U., Giles, T., Gorska, M., Hannawald, M., Huyse, M., Joinet, A., Jonsson, O.C., Kratz, K.L., Kruglov, K., Lau, Ch., Lettry, J., Mishin, V.I., Oinonen, M., Partes, K., Peräjärvi, K., Pfeiffer, B., Ravn, H.L., Seliverstov, M.D., Thirolf, P., Van de Vel, K., Van Duppen, P., Van Roosbroeck, J., and Weissman, L., Nucl. Instrum. Methods Phys. Res. Sect. B: Beam Interact. Mater. At., 2003, vol. 204, pp. 347–352.

    Article  CAS  Google Scholar 

  12. Verhoeven, H., Cocolios, T.E., Dockx, K., Farooq-Smith, G.J., Felden, O., Formento-Cavaier, R., Gebel, R., Köster, U., Neumaier, B., Scholten, B., Spahn, I., Spellerberg, S., Stamati, M.E., and Stegemann, S., Nucl. Instrum. Meth. Phys. Res. Sect. B Beam Interact. Mater. At., 2020, vol. 463. January, pp. 327–329.

    Article  CAS  Google Scholar 

  13. Abbas Rizvi, S.M., Henniker, A.J., and Goozee, G., Allen, B.J., Leuk. Res., 2002, vol. 26, no. 1, pp. 37–43.

    Article  PubMed  Google Scholar 

  14. Miederer, M., Seidl, C., Beyer, G-J., Charlton, D.E., Vranješ-Durić, S., Comor, J.J., Huber, R., Nikula, T., Apostolidis, C., Schuhmacher, C., Becker K-F., and Senekowitsch-Schmidtke, R., Radiat. Res., 2003, vol. 159, no. 5, pp. 612–620.

    Article  CAS  PubMed  Google Scholar 

  15. Beyer, G.-J., Miederer, M., Vranješ-Durić, S., Čomor, J.J., Künzi, G., Hartley, O., Senekowitsch-Schmidtke, R., Soloviev, D., and Buchegger, F., Eur. J. Nucl. Med. Mol. Imaging., 2004, vol. 31, no. 4, pp. 547–554.

    Article  CAS  PubMed  Google Scholar 

  16. Müller, C., Zhernosekov, K., Köster, U., Johnston, K., Dorrer, H., Hohn, A., Van Der Walt, N.T., Türler, A., and Schibli, R., J. Nucl. Med., 2012, vol. 53, no. 12, pp. 1951–1959.

    Article  PubMed  CAS  Google Scholar 

  17. Umbricht, C.A., Köster, U., Bernhardt, P., Gracheva, N., Johnston, K., Schibli, R., van der Meulen, N.P., and Müller, C., Sci. Rep., 2019, vol. 9, no. 1, pp. 1–10.

    Article  CAS  Google Scholar 

  18. Zagryadskii, V.A., Latushkin, S.T., Malamut, T.Y., Novikov, V.I., Ogloblin, A.A., Unezhev, V.N., and Chuvilin, D.Y., At. Energy, 2017, vol. 123, no. 1, pp. 55–58.

    Article  CAS  Google Scholar 

  19. Moiseeva, A.N., Aliev, R.A., Unezhev, V.N., Zagryadskiy, V.A., Latushkin, S.T., Aksenov, N.V., Gustova, N.S., Voronuk, M.G., Starodub, G.Y., and Ogloblin, A.A., Sci. Rep., 2020, vol. 10, no. 1, pp. 1–7.

    Article  CAS  Google Scholar 

  20. Steyn, G.F., Vermeulen, C., Szelecsényi, F., Kovács, Z., Hohn, A., van der Meulen, N.P., Schibli, R., and van der Walt, T.N., Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. At., 2014, vol. 319, pp. 128–140.

    Article  CAS  Google Scholar 

  21. Formento-Cavaier, R., Haddad, F., Alliot, C., Sounalet, T., and Zahi, I., Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. At., 2020, vol. 478. June, pp. 174–181.

    Article  CAS  Google Scholar 

  22. Zaitseva, N.G., Dmitriev, S.N., Maslov, O.D., Molokanova, L.G., Starodub, G.Y., Shishkin, S.V., Shishkina, T.V., and Beyer, G.J., Czechoslov. J. Phys., 2003, vol. 53, no. S1, pp. A455–A458.

    Article  Google Scholar 

  23. Sarkar, S., Allen, B.J., Iman, S., Gouzee, G., Leigh, J., and Meriaty, H., Abstracts of Pspers, Second Int. Conf. on Isotopes., Sydney, 1997.

  24. Maiti, M., Lahiri, S., and Tomar, B.S., Radiochim. Acta, 2011, vol. 99, no. 9, pp. 527–534.

    Article  CAS  Google Scholar 

  25. Maiti, M., Phys. Rev. C: Nucl. Phys., 2011, vol. 84, no. 4, pp. 1–7.

    Google Scholar 

  26. Allen, B.J., Goozee, G., Sarkar, S., Beyer, G.J., Morel, C., and Byrne, A.P., Appl. Radiat. Isot., 2001, vol. 54, no. 1, pp. 53–58.

    Article  CAS  PubMed  Google Scholar 

  27. Baum, R.P., Singh, A., Benešová, M., Vermeulen, C., Gnesin, S., Köster, U., Johnston, K., Müller, D., Senftleben, S., Kulkarni, H.R., Türler, A., Schibli, R., Prior, J.O., Van Der Meulen, N.P., and Müller, C., Dalton Trans., 2017, vol. 46, no. 42, pp. 14638–14646.

    Article  CAS  PubMed  Google Scholar 

  28. Müller, C., Vermeulen, C., Johnston, K., Köster, U., Schmid, R., Türler, A., van der Meulen, N.P., EJNMMI Res., 2016, vol. 6, no. 1.

  29. Cicone, F., Gnesin, S., Denoël, T., Stora, T., van der Meulen, N.P., Müller, C., Vermeulen, C., Benešová, M., Köster, U., Johnston, K., Amato, E., Auditore, L., Coukos, G., Stabin, M., Schaefer, N., Viertl, D., and Prior, J.O., EJNMMI Res., 2019, vol. 9, ID 53.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Müller, C., Singh, A., Umbricht, C.A., Kulkarni, H.R., Johnston, K., Benešová, M., Senftleben, S., Müller, D., Vermeulen, C., Schibli, R., Köster, U., van der Meulen, N.P., and Baum, R.P., EJNMMI Res., 2019, vol. 9, no. 1, pp. 1–10.

    Article  CAS  Google Scholar 

  31. Vermeulen, C., Steyn, G.F., Szelecsényi, F., Kovács, Z., Suzuki, K., Nagatsu, K., Fukumura, T., Hohn, A., and van der walt, T.N., Nucl. Instrum. Methods Phys. Res. Sect. B: Beam Interact. Mater. At., 2012, vol. 275, pp. 24–32.

    Article  CAS  Google Scholar 

  32. Güray, R.T., Özkan, N., Yalçln, C., Rauscher, T., Gyürky, G., Farkas, J., Fülöp, Z., Halász, Z., and Somorjai, E., Phys. Rev. C: Nucl. Phys., 2015, vol. 91, no. 5, pp. 1–9.

    Article  CAS  Google Scholar 

  33. Köster, U., Assmann, W., Bacri, C.-O., Faestermann, T., Garrett, P., Gernhäuser, R., Tomandl, I., Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. At., 2020, vol. 463. February, pp. 111–114.

    Article  CAS  Google Scholar 

  34. Tárkányi, F., Ditrói, F., Takács, S., Hermanne, A., and Ignatyuk, A.V., Appl. Radiat. Isot., 2015, vol. 98, pp. 87–95.

    Article  PubMed  CAS  Google Scholar 

  35. Nayak, D., Lahiri, S., Ramaswami, A., Manohar, S.B., and Das, N.R., Appl. Radiat. Isot., 1999, vol. 51, no. 6, pp. 631–636.

    Article  CAS  PubMed  Google Scholar 

  36. Lahiri, S., Nayak, D., Das, S.K., Ramaswami, A., Manohor, S.B., and Das, N.R., J. Radioanal. Nucl. Chem., 1999, vol. 241, no. 1, pp. 201–206.

    Article  CAS  Google Scholar 

  37. Webster, B., Ivanov, P., Russell, B., Collins, S., Stora, T., Ramos, J.P., Köster, U., Robinson, A.P., and Read, D., Sci. Rep., 2019, vol. 9, no. 1, pp. 10884–10893.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Gayoso, R.E., Sonzogni, A.A., and Nassiff, S.J., Radiochim. Acta. 1996, vol. 72, no. 2, pp. 55–60.

    Article  CAS  Google Scholar 

  39. Szelecsényi, F., Kovács, Z., Nagatsu, K., Zhang, M.R., and Suzuki, K., J. Radioanal. Nucl. Chem., 2016, vol. 307, no. 3, pp. 1877–1881.

    Article  CAS  Google Scholar 

  40. Gayoso, R.E., Barral, M.A., and Nassiff, S.J., J. Radioanal. Nucl. Chem., 1997, vol. 218, no. 2, pp. 223–227.

    Article  CAS  Google Scholar 

  41. Tárkányi, F., Ditrói, F., Takács, S., Hermanne, A., and Ignatyuk, A.V., Ann. Nucl. Energy, 2013, vol. 62, pp. 375–381.

    Article  CAS  Google Scholar 

  42. Tárkányi, F., Ditrói, F., Takács, S., Csikai, J., Hermanne, A., and Ignatyuk, A.V., Appl. Radiat. Isot., 2015, vol. 83, pp. 18–24.

    Article  CAS  Google Scholar 

  43. Shahid, M., Kim, K., Naik, H., and Kim, G., Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. At., 2019, vol. 464. December, pp. 74–83.

    Article  CAS  Google Scholar 

  44. Kazakov, A.G., Aliev, R.A., Bodrov, A.Y., Priselkova, A.B., and Kalmykov, S.N., Radiochim. Acta, 2018, vol. 106, no. 2, pp. 135–140.

    Article  CAS  Google Scholar 

  45. Giri, P.K., Mahato, A., Singh, D., Linda, S.B., Kumar, H., Tali, S.A., and Ali, R., Indian J. Pure Appl. Phys., 2019, vol. 57. September, pp. 619–623.

    Google Scholar 

  46. Giri, P.K., Singh, D., Linda, S.B., Mahato, A., Kumar, H., Tali, S.A., Afzal Ansari, M., Kumar, R., Singh, R.P., and Muralithar, S., Indian J. Pure Appl. Phys., 2019, vol. 57, no. 8, pp. 552–556.

    Google Scholar 

  47. Müller, C., Fischer, E., Behe, M., Köster, U., Dorrer, H., Reber, J., Haller, S., Cohrs, S., Blanc, A., Grünberg, J., Bunka, M., Zhernosekov, K., van der Meulen, N.P., Johnston, K., Türler, A., and Schibli, R., Nucl. Med. Biol., 2014, vol. 41, no. S, pp. 58–65.

    Article  CAS  Google Scholar 

  48. Jakobsson, U., Mäkilä, E., Rahikkala, A., Imlimthan, S., Lampuoti, J., Ranjan, S., Heino, J., Jalkanen, P., Köster, U., Mizohata, K., Santos, H.A., Salonen, J., Airaksinen, A.J., Sarparanta, M., and Helariutta, K., Nucl. Med. Biol., 2020, vol. 84–85, pp. 102–110.

    Article  PubMed  CAS  Google Scholar 

  49. Lehenberger, S., Barkhausen, C., Cohrs, S., Fischer, E., Grünberg, J., Hohn, A., Köster, U., Schibli, R., Türler, A., and Zhernosekov, K., Nucl. Med. Biol., 2011, vol. 38, no. 6, pp. 917–924.

    Article  CAS  PubMed  Google Scholar 

  50. Szelecsényi, F., Fenyvesi, A., Steyn, G.F., Brezovcsik, K., Kovács, Z., Biró, B., J. Radioanal. Nucl. Chem., 2018, vol. 318, no. 1, pp. 491–496.

    Article  CAS  Google Scholar 

  51. Tárkányi, F., Hermanne, A., Takács, S., Ditrói, F., Csikai, J., and Ignatyuk, A.V., J. Radioanal. Nucl. Chem., 2013, vol. 298, no. 2, pp. 1385–1392.

    Article  CAS  Google Scholar 

  52. Monroy-Guzman, F., and Salinas, E.J., J. Mex. Chem. Soc., 2015, vol. 59, no. 2, pp. 143–150.

    CAS  Google Scholar 

  53. Aziz, A., Artha, W.T., Indones. J. Chem., 2017, vol. 16, no. 3, pp. 283–288.

    Article  Google Scholar 

  54. Aziz, A., J. Phys. Conf. Ser., 2020, vol. 1436, no. 1, ID 012097.

    Article  CAS  Google Scholar 

  55. Müller, C. and Schibli, R., Front. Oncol., 2013, vol. 3. September, pp. 1–10.

    Article  CAS  Google Scholar 

  56. Zhang, J., Singh, A., Kulkarni, H.R., Schuchardt, C., Müller, D., Wester, H.J., Maina, T., Rösch, F., van der Meulen, N.P., Müller, C., Mäcke, H., and Baum, R.P., Semin. Nucl. Med., 2019, vol. 49, no. 5, pp. 422–437.

    Article  PubMed  Google Scholar 

  57. Grünberg, J., Lindenblatt, D., Dorrer, H., Cohrs, S., Zhernosekov, K., Köster, U., Türler, A., and Fischer, E., Schibli, R., Eur. J. Nucl. Med. Mol. Imaging., 2014, vol. 41, no. 10, pp. 1907–1915.

    Article  PubMed  CAS  Google Scholar 

  58. Müller, C., Reber, J., Haller, S., Dorrer, H., Bernhardt, P., Zhernosekov, K., Türler, A., and Schibli, R., Eur. J. Nucl. Med. Mol. Imaging., 2014, vol. 41, no. 3, pp. 476–485.

    Article  PubMed  CAS  Google Scholar 

  59. Haller, S., Pellegrini, G., Vermeulen, C., van der Meulen, N.P., Köster, U., Bernhardt, P., Schibli, R., and Müller, C., EJNMMI Res., 2016, vol. 6, no. 1, pp. 1–11.

    Article  CAS  Google Scholar 

  60. Müller, C., Umbricht, C.A., Gracheva, N., Tschan, V.J., Pellegrini, G., Bernhardt, P., Zeevaart, J.R., Köster, U., Schibli, R., and van der Meulen, N.P., Eur.J. Nucl. Med. Mol. Imaging., 2019, vol. 46, no. 9, pp. 1919–1930.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  61. Nizou, G., Favaretto, C., Borgna, F., Grundler, P.V., Saffon-Merceron, N., Platas-Iglesias, C., Fougère, O., Rousseaux, O., van der Meulen, N.P., Müller, C., Beyler, M., and Tripier, R., Inorg. Chem., 2020, vol. 59. N 16, pp. 11736–11748.

    Article  CAS  PubMed  Google Scholar 

  62. Marin, I., Rydèn, T., van Essen, M., Svensson, J., Gracheva, N., Köster, U., Zeevaart, J.R., van der Meulen, N.P., Müller, C., and Bernhardt, P., EJNMMI Phys., 2020, vol. 7, no. 1.

Download references

ACKNOWLEDGMENTS

The author thanks Academician B.F. Myasoedov and S.E. Vinokurov (Laboratory of Radiochemistry, GEOKHI RAS) for helpful comments on the study.

Funding

The study was carried out with the financial support of the Russian Foundation for Basic Research within the framework of scientific project no. 20-13-50166.

Author information

Authors and Affiliations

  1. Vernadsky Institute of Geochemistry and Analytical Chemistry, 119991, Russian Academy of Sciences, Russia

    A. G. Kazakov

Authors
  1. A. G. Kazakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. G. Kazakov.

Ethics declarations

The author declares no conflict of interest.

Additional information

Translated from Radiokhimiya, No. 2, pp. 103–119, April, 2022 https://doi.org/10.31857/S0033831122020010

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kazakov, A.G. Terbium Isotopes in Nuclear Medicine: Production, Recovery, and Application. Radiochemistry 64, 103–119 (2022). https://doi.org/10.1134/S1066362222020011

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1066362222020011

Keywords:

Search

Navigation