Abstract
Convenient preparative ways to synthesize tritium-labeled non-natural derivatives containing the cytosine and guanine moieties have been developed. The main distinction of these compounds from those already known consists in that they contain a chiral center. The tritium-labeled 2'-desoxy-3'-oxacytidine can was synthesized by the reaction of catalytic dehalogenation in solution of the corresponding 5-bromine-substituted compound; for 6-aminocyclopropyl-2'-desoxy-3'-oxaguanosine, the reaction of catalytic heterogeneous catalytic exchange in solution was used; for rest of compounds, the reaction of solid-phase catalytic hydrogenation (SCH) was employed.
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Sidorov, G.V., Myasoedov, N.F. Synthesis of Tritium-Labeled Non-Natural Analogs of Purine and Pyrimidine Nucleosides. Radiochemistry 62, 255–259 (2020). https://doi.org/10.1134/S1066362220020149
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DOI: https://doi.org/10.1134/S1066362220020149