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Radioiodination and biological evaluation of rabeprazole as a peptic ulcer localization radiotracer

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Radiochemistry Aims and scope

Abstract

Rabeprazole, a proton pump inhibitor, was labeled with 131I to give 131I-rabeprazole in 98% yield. The optimum conditions were as follows: pH 8, 100 μg of chloramine-T, 30 min, and 0.2 mg of rabeprazole. The labeled compound was stable for 24 h. Biodistribution of 131I-rabeprazole in mice after intravenous injection was studied, and its high uptake in stomach ulcer, reaching approximately 38% ID/g at 1 h post injection, was demonstrated. This concentration of the labeled compound in stomach ulcer is sufficient for ulcer imaging. The advantages of the method are simple labeling procedure, high labeling yield, and high sensitivity of ulcer imaging.

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Authors and Affiliations

  1. Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad

  2. Nuclear Physics Department, Cyclotrone Project, Nuclear Research Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    S. B. Challan

Authors
  1. M. H. Sanad
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  2. S. B. Challan
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Correspondence to M. H. Sanad.

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Sanad, M.H., Challan, S.B. Radioiodination and biological evaluation of rabeprazole as a peptic ulcer localization radiotracer. Radiochemistry 59, 307–312 (2017). https://doi.org/10.1134/S1066362217030158

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