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Nuclear-chemical synthesis of tritium-labeled fluorinated isoquinolinium derivatives

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Radiochemistry Aims and scope

Abstract

The developed nuclear-chemical method allows direct phenylation of the nitrogen atom in the isoquinoline molecule and one-step synthesis of tritium-labeled biomarkers containing previously unknown N-(p-difluorophenyl)isoquinolinium fragment with high radiochemical yield.

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Authors and Affiliations

  1. Natural Science Institute, Perm State National Research University, ul. Genkelya 4, Perm, 614990, Russia

    N. E. Shchepina

  2. St. Petersburg State University, Universitetskaya nab., 7–9, St. Petersburg, 199034, Russia

    V. V. Avrorin

  3. Radiochemistry Chair, Chemical Faculty, Moscow State University, Moscow, Russia

    G. A. Badun

  4. Perm State National Research University, ul. Bukireva 15, Perm, 614990, Russia

    S. N. Shurov

  5. Medical Center North, Vanderbilt University, 1161 21st Avenue South, AA-1105, Nashville, TN, USA

    R. V. Shchepin

Authors
  1. N. E. Shchepina
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  2. V. V. Avrorin
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  3. G. A. Badun
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  4. S. N. Shurov
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  5. R. V. Shchepin
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Corresponding author

Correspondence to N. E. Shchepina.

Additional information

Original Russian Text © N.E. Shchepina, V.V. Avrorin, G.A. Badun, S.N. Shurov, R.V. Shchepin, 2017, published in Radiokhimiya, 2017, Vol. 59, No. 3, pp. 260–263.

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Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. Nuclear-chemical synthesis of tritium-labeled fluorinated isoquinolinium derivatives. Radiochemistry 59, 297–300 (2017). https://doi.org/10.1134/S1066362217030134

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  • DOI: https://doi.org/10.1134/S1066362217030134

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