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Synthesis of tritium-labeled Ganciclovir

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Radiochemistry Aims and scope

Abstract

The influence of temperature on the solid-phase isotope exchange of Ganciclovir with tritium was studied. Synthesis conditions were found, and tritium-labeled Ganciclovir with the molar radioactivity of 25 Ci mmol−1 (0.925 PBq mol−1) and purity higher than 98% was prepared.

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References

  1. Sidorov, G.V. and Myasoedov, N.F., Bioorg. Khim., 1993, vol. 19, no. 12, pp. 1220–1225.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akad. Kurchatova 2, Moscow, 123182, Russia

    G. V. Sidorov & N. F. Myasoedov

Authors
  1. G. V. Sidorov
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  2. N. F. Myasoedov
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Correspondence to G. V. Sidorov.

Additional information

Original Russian Text © G.V. Sidorov, N.F. Myasoedov, 2011, published in Radiokhimiya, 2011, Vol. 53, No. 6, pp. 545–546.

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Sidorov, G.V., Myasoedov, N.F. Synthesis of tritium-labeled Ganciclovir. Radiochemistry 53, 646–647 (2011). https://doi.org/10.1134/S1066362211060130

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  • DOI: https://doi.org/10.1134/S1066362211060130

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