Abstract
Selective agonists of cannabinoid receptors Win 55 212 and CP 55 940, labeled with hydrogen isotopes, were prepared. The content of isotopomers in deuterium-labeled Win 55 212 and CP 55 940, and also the deuterium distribution in fragments of the [2H]Win 55212 molecule were determined by mass spectrometry. [3H]Win 55 212 and [3H]CP 55 940 with molar radioactivities of 55 and 70 Ci mmol−1, respectively, were prepared by the reaction with gaseous tritium. The efficiency of isotope exchange with activated hydrogen species under the conditions of primary and secondary hydrogen spillover is discussed.
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Original Russian Text © V.P. Shevchenko, V.V. Bezuglov, M.Yu. Bobrov, I.Yu. Nagaev, N.F. Myasoedov, 2010, published in Radiokhimiya, 2010, Vol. 52, No. 3, pp. 281–284.
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Shevchenko, V.P., Bezuglov, V.V., Bobrov, M.Y. et al. Introduction of hydrogen isotopes into Win 55212 and CP 55940, selective agonists of cannabinoid receptors. Radiochemistry 52, 330–334 (2010). https://doi.org/10.1134/S1066362210030197
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DOI: https://doi.org/10.1134/S1066362210030197