Abstract
Specific features of sorption of sodium [3H]succinate on nanohydroxyapatite (HAP) and its hierarchic textures were studied by radionuclide-microscopic diagnostics. Chemisorption of sodium succinate leads to structural-morphological modification of HAP, manifested, in particular, in changes in the habit of individual nanocrystals and in the internal texture of HAP macrospheroids. The dynamics of sorption penetration of sodium succinate into macrospherical HAP granules was monitored by autoradiogarphy. The results obtained suggest that nanohydroxyapatite and textured products based on it can be used for the development of materials for drug transport and of complex succinic acid containing preparations for medical purpose.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Severin, A.V., Bozhevol’nov, V.E., Komarov, V.F., and Melikhov, I.V., Zh. Neorg. Khim., 2005, vol. 50, no. 1, pp. 76–81.
Suchanek, W. and Yoshimura, M., J. Mater. Res., 1998, vol. 13, no. 1, pp. 94–117.
Orlovskii, V.P. and Barinov, S.M., Russ. J. Inorg. Chem., 2001, vol. 46, suppl. no. 2, pp. 129–149.
Kester, M., Heakal, Y., and Fox, T., Nano Lett., 2008, vol. 8, no. 12, pp. 4116–4121.
Ming-Yan Ma, Ying-Jie Zhu, Liang Li, and Shao-Wen Cao, J. Mater. Chem., 2008, vol. 18, pp. 2722–2727.
Severin, A.V., Badun, G.A., and Tyasto, Z.A., Radiokhimiya, 2009, vol. 51, no. 1, pp. 47–50.
Melikhov, I.V., Komarov, V.F., Bozhevol’nov, V.E., and Severin, A.V., Dokl. Ross. Akad. Nauk, 2000, vol. 373, no. 3, pp. 355–358.
Severin, A.V., Radionuclide-Microscopic Diagnostics of the Evolution of Sparingly Soluble Dispersed Substances, with Calcium Sulfate Dihydrate and Hydroxyapatite as Examples, Cand. Sci. (Chem.) Dissertation, Moscow, 2008, pp. 144–147.
Baratova, L.A., Bogacheva, E.N., Gol’danskii, V.I., et al., Tritievaya planigrafiya biologicheskikh makromolekul (Tritium Planigraphy of Biological Macromolecules), Moscow: Nauka, 1999.
Melikhov, I.V., Teterin, Yu.A., Rudin, V.N., et al., Zh. Fiz. Khim., 2009, vol. 83, no. 1, pp. 1–7.
Andriyanov, A.Yu., Autoradiography Using Various Activation Sources and Computer Treatment Procedures for Determining Noble Metals in Geological Samples, Cand. Sci. (Phys.-Math.) Dissertation, Moscow, 2004.
Suvorova, E.I., Klechkovskaya, V.V., Komarov, V.F., et al., Kristallografiya, 2006, vol. 51, no. 5, pp. 939–946.
Prest, W.M. and Luca, D.J., J. Appl. Phys., 1978, vol. 49, no. 10, p. 5042.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.V. Severin, G.A. Badun, Z.A. Tyasto, V.I. Korobkov, V.N. Rudin, 2009, published in Radiokhimiya, 2009, Vol. 51, No. 6, pp. 551–554.
Rights and permissions
About this article
Cite this article
Severin, A.V., Badun, G.A., Tyasto, Z.A. et al. A radionuclide-microscopic study of sorption of sodium [3H]succinate on textured nanohydroxyapatite. Radiochemistry 51, 633–637 (2009). https://doi.org/10.1134/S1066362209060137
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1066362209060137