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211At-Rh(16-S4-diol) as a starting complex for preparing an astatine-labeled radiopharmaceutical

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Radiochemistry Aims and scope

Abstract

A new procedure for preparing an 211At-labeled radiopharmaceutical is suggested. The 211At− anion forms a strong bond with the Rh3+ cation incorporated in the complex with a thiother ligand, 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16-S4-diol). The reaction conditions are optimized with 131I as astatine analog. The complexes are studied by paper electrophoresis, ion exchange, and thin-layer chromatography. The kinetics of the addition of the 131I− anion to Rh(16-S4-diol) and the dependence of the yield of the forming complex 131I-Rh(16-S4-diol) on the temperature, solution acidity, and reactant concentrations are examined. Taking into account the results obtained, the complex 211At-Rh(16-S4-diol) is prepared by adding astatide (211 At−) to equivalent amounts of RhCl3 and the tetrathioether (16-S4-diol). the behavior of the astatine complex is studied.

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Authors and Affiliations

  1. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Moscow oblast, Russia

    Yu. V. Norseev

  2. Department of Radiochemistry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland

    A. Bilewicz & M. Pruszynski

Authors
  1. Yu. V. Norseev
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  2. A. Bilewicz
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  3. M. Pruszynski
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Original Russian Text © Yu.V. Norseev, A. Bilewicz, M. Pruszynski, 2008, published in Radiokhimiya, 2008, Vol. 50, No. 2, pp. 178–182.

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Norseev, Y.V., Bilewicz, A. & Pruszynski, M. 211At-Rh(16-S4-diol) as a starting complex for preparing an astatine-labeled radiopharmaceutical. Radiochemistry 50, 208–212 (2008). https://doi.org/10.1134/S1066362208020239

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  • DOI: https://doi.org/10.1134/S1066362208020239

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