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Synthesis of 2-[18F]Fluoro-L-tyrosine and comparative study of its uptake by rat glioma 35 tumor and by induced inflammation focus in experimental animals

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Abstract

2-[18F]Fluoro-L-tyrosine (2-[18F]FTYR), a labeled fluorinated analog of tyrosine, was prepared using chiral phase-transfer catalysis. The radiochemical yield of 2-[18F]FTYR corrected for radioactive decay was 25±6% (n = 15) at a synthesis time of 110–120 min, including semipreparative HPLC purification. The radiochemical and chemical purity of the product exceeded 99%, and the enantiomeric purity was 98.2±0.7% (n = 15). The uptake of 2-[18F]FTYR by tumors and abscesses in laboratory animals was studied. The ratios of radioactivity uptake by tumor or imflamed tissue to that of an intact muscle tissue were calculated. Within the time of experiment, the tumor/muscle ratio exceeds the abscess/muscle ratio. The results obtained allow 2-[18F]FTYR to be considered as potentially useful radiotracer for differential diagnostics of tumors and inflammations by PET.

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Authors and Affiliations

  1. Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

    O. S. Fedorova, O. F. Kuznetsova, I. K. Mosevich, S. V. Shatik, G. V. Kataeva & R. N. Krasikova

  2. Central Research Institute of Roentgenology and Radiology, St. Petersburg, Russia

    S. V. Shatik

  3. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

    Yu. N. Belokon’

Authors
  1. O. S. Fedorova
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  2. O. F. Kuznetsova
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  3. I. K. Mosevich
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  4. S. V. Shatik
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  5. G. V. Kataeva
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  6. Yu. N. Belokon’
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  7. R. N. Krasikova
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Original Russian Text © O.S. Fedorova, O.F. Kuznetsova, I.K. Mosevich, S.V. Shatik, G.V. Kataeva, Yu.N. Belokon’, R.N. Krasikova, 2006, published in Radiokhimiya, 2006, Vol. 48, No. 5, pp. 458–462.

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Fedorova, O.S., Kuznetsova, O.F., Mosevich, I.K. et al. Synthesis of 2-[18F]Fluoro-L-tyrosine and comparative study of its uptake by rat glioma 35 tumor and by induced inflammation focus in experimental animals. Radiochemistry 48, 509–514 (2006). https://doi.org/10.1134/S1066362206050201

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  • DOI: https://doi.org/10.1134/S1066362206050201

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