Abstract
The tert-butyloxycarbonyl derivative of Met-Glu-His-Phe-Pro-Gly was prepared and condensed with either unsaturated or labeled proline. The unsaturated peptide protected by the tert-butyloxycarbonyl group was hydrogenated with gaseous tritium in the presence of a catalyst. The Semax analog labeled in the proline fragment was deprotected by acid hydrolysis. The molar radioactivity of the product (PBq mol−1) reached 0.93 in the route via labeled proline and 0.37 in the route via unsaturated Semax analog.
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Original Russian Text © V.P. Shevchenko, I.Yu. Nagaev, L.Yu. Alfeeva, L.A. Andreeva, P.A. Klimova, K.V. Shevchenko, A.V. Malkin, N.F. Myasoedov, 2006, published in Radiokhimiya, 2006, Vol. 48, No. 3, pp. 260–266.
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Shevchenko, V.P., Nagaev, I.Y., Alfeeva, L.Y. et al. Synthesis of tritium-labeled Semax. Radiochemistry 48, 288–295 (2006). https://doi.org/10.1134/S1066362206030155
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DOI: https://doi.org/10.1134/S1066362206030155