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Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy

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Abstract

The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force microscopy, it is established that exposure to ouabain, in contrast to the impact of comenic acid, leads to a hardening of the neuron soma. This suggests that the receptor-coupled signal transmission to the cell genome is carried out through mechanisms that are different from the transducer-coupled signal pathways.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia

    M. M. Khalisov, V. A. Penniyaynen & B. V. Krylov

  2. St. Petersburg National Research University of Information Technologies, Mechanics, and Optics, St. Petersburg (ITMO University), St. Petersburg, 197101, Russia

    M. M. Khalisov & A. V. Ankudinov

  3. Institute for Analytical Instrumentation, Russian Academy of Sciences, St. Petersburg, 198095, Russia

    N. A. Esikova

  4. Ioffe Physical Technical Institute, Russian Academy of Sciences, St. Petersburg, 194021, Russia

    A. V. Ankudinov

Authors
  1. M. M. Khalisov
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  2. V. A. Penniyaynen
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  3. N. A. Esikova
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  4. A. V. Ankudinov
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  5. B. V. Krylov
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Corresponding author

Correspondence to A. V. Ankudinov.

Additional information

Original Russian Text © M.M. Khalisov, V.A. Penniyaynen, N.A. Esikova, A.V. Ankudinov, B.V. Krylov, 2017, published in Pis’ma v Zhurnal Tekhnicheskoi Fiziki, 2017, Vol. 43, No. 1, pp. 89–94.

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Khalisov, M.M., Penniyaynen, V.A., Esikova, N.A. et al. Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy. Tech. Phys. Lett. 43, 85–87 (2017). https://doi.org/10.1134/S1063785017010072

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  • DOI: https://doi.org/10.1134/S1063785017010072

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