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Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering

  • 23rd INTERNATIONAL SYMPOSIUM “NANOPHYSICS AND NANOELECTRONICS,” Nizhny Novgorod, March 11–14, 2019
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Abstract

The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-ε-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.

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Funding

This study was supported by the Russian Foundation for Basic Research (grant no. 17-53-61026 Egypt_a) and the Egyptian Academy of Sciences (project STDF no. 26599).

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, St. Petersburg, Russia

    T. E. Sukhanova, M. E. Vylegzhanina, A. Ya. Volkov, E. R. Gasilova & A. A. Kutin

  2. Lebedev Research Institute of Synthetic Rubber, 198035, St. Petersburg, Russia

    T. E. Sukhanova

  3. Department of Polymers and Pigments, National Research Center, 12622, Dokki, Giza, Cairo, Egypt

    Moshera Samy, Heba M. Abdallah & Magdy M. H. Ayoub

Authors
  1. T. E. Sukhanova
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  2. M. E. Vylegzhanina
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  3. A. Ya. Volkov
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  4. E. R. Gasilova
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  5. A. A. Kutin
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  6. Moshera Samy
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  7. Heba M. Abdallah
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  8. Magdy M. H. Ayoub
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Correspondence to T. E. Sukhanova.

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Translated by E. Glushachenkova

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Sukhanova, T.E., Vylegzhanina, M.E., Volkov, A.Y. et al. Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering. Tech. Phys. 64, 1729–1737 (2019). https://doi.org/10.1134/S1063784219120235

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  • DOI: https://doi.org/10.1134/S1063784219120235

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