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Immobilization of Photoditazine on Vaterite Porous Particles and Analysis of the System Stability in Model Media

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Abstract

In this paper, we present the results on immobilization of Photoditazine, the photosensitizer of the second generation, on vaterite (metastable modification of calcium carbonate) porous particles of two different sizes. The adsorption efficiency is found to be 3.0 and 3.2 wt % Photoditazine on vaterite particles with average diameters of 5 and 0.5 μm, respectively. The curves of Photoditazine desorption from vaterite particles are determined depending on the composition of the dispersion medium (water and bovine serum albumin solution). It is found that vaterite particles in water are subjected to recrystallization in accordance with the dissolution–precipitation mechanism. The presence of albumin molecules at a physiological concentration allows stabilizing metastable vaterite particles of micron and submicron size for at least 17 days.

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ACKNOWLEDGMENTS

This work was performed on the equipment of the Shared Research Center of Federal Scientific Center “Crystallography and Photonics,” Russian Academy of Sciences, and was supported by the Ministry of Education and Science of the Russian Federation. The study was performed using the equipment of the National Research Center “Kurchatov Institute.” The work was supported by the Federal Agency of Scientific Organizations (agreement no. 007-ГЗ/Ч3363/26).

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Authors and Affiliations

  1. National Research Center Kurchatov Institute, 123098, Moscow, Russia

    D. B. Trushina & T. V. Bukreeva

  2. Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    D. B. Trushina & T. N. Borodina

  3. Shubnikov Institute of Crystallography, Federal Scientific Research Center “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

    D. B. Trushina, T. N. Borodina, V. V. Artemov & T. V. Bukreeva

Authors
  1. D. B. Trushina
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  2. T. N. Borodina
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  3. V. V. Artemov
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  4. T. V. Bukreeva
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Correspondence to D. B. Trushina.

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Translated by N. Wadhwa

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Trushina, D.B., Borodina, T.N., Artemov, V.V. et al. Immobilization of Photoditazine on Vaterite Porous Particles and Analysis of the System Stability in Model Media. Tech. Phys. 63, 1345–1351 (2018). https://doi.org/10.1134/S1063784218090220

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  • DOI: https://doi.org/10.1134/S1063784218090220

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