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Radiochemical Investigations for Radiopharmaceutical Nuclear Medicine at JINR Laboratory of Nuclear Problems

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Abstract

In recent years, radiopharmaceuticals have been increasingly used for diagnostics and treatment of cancer. In addition to a biological vector, a modern radiopharmaceutical includes a chelator that binds the radionuclide, as well as a linker for connecting the vector and the chelator. The development of such an approach requires the improvement of methods for obtaining and purifying radionuclides, and the development of methods for the synthesis of radiopharmaceuticals, i.e., preparative direction. It is also necessary to search for new vectors and chelators. This implies the development of methods for analyzing the properties of radiopharmaceuticals in general, as well as their precursors, i.e., analytical direction. In this review, we describe the prerequisites for successfully solving a wide range of challenges in these two areas of nuclear medicine at the Scientific and Experimental Department of Nuclear Spectroscopy and Radiochemistry of the Laboratory of Nuclear Problems of the Joint Institute for Nuclear Research (LNP JINR). These prerequisites are due to rich experience in obtaining the widest range of radionuclides and their application for various spectrometric studies. Both the past and present works on radiopharmaceutical topics carried out in the department are described, and ways of future development are outlined.

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ACKNOWLEDGMENTS

We thank Dr. Peter Kunz, our colleague from TRIUMF, for the theoretical calculation of radionuclide yields with Geant4 when irradiating the tantalum target (Fig. 3).

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, 141980, Dubna, Moscow oblast, Russia

    D. V. Filosofov, A. E. Baimukhanova, E. S. Kurakina, D. V. Karaivanov, A. I. Velichkov & E. A. Yakushev

  2. Institute of Nuclear Physics, 050032, Almaty, Kazakhstan

    A. E. Baimukhanova

  3. Mendeleev University of Chemical Technology, 125480, Moscow, Russia

    A. E. Baimukhanova & E. S. Kurakina

  4. Institute for Nuclear Research and Nuclear Energy, 1784, Sofia, Bulgaria

    D. V. Karaivanov & A. I. Velichkov

  5. The University of British Columbia, V6T 1Z4, West Mall 2329, Vancouver, Canada

    V. I. Radchenko

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  1. D. V. Filosofov
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  2. A. E. Baimukhanova
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  3. E. S. Kurakina
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  4. D. V. Karaivanov
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  5. A. I. Velichkov
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  6. V. I. Radchenko
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  7. E. A. Yakushev
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Correspondence to A. E. Baimukhanova.

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Translated by G. Dedkov

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Filosofov, D.V., Baimukhanova, A.E., Kurakina, E.S. et al. Radiochemical Investigations for Radiopharmaceutical Nuclear Medicine at JINR Laboratory of Nuclear Problems. Phys. Part. Nuclei 54, 321–363 (2023). https://doi.org/10.1134/S106377962302003X

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  • DOI: https://doi.org/10.1134/S106377962302003X

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