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Neutrons against cancer

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Abstract

The review is devoted to the analysis and generalization of the research carried out during recent years in industrially advanced countries on the use of fast, epithermal, and thermal neutrons for therapy of malignant tumors. Basic facilities for neutron production used for cancer treatment are presented. Optimal parameters of therapeutic beams are described. Techniques using neutrons of different energy regions are discussed. Results and medical treatment efficiency are given. Comparison of the current state of neutron therapy of tumors and alternative treatments with beams of protons and carbon ions has been conducted. Main attention is given to the possibility of the practical use of accumulated experience of application of neutron beams for cancer therapy.

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References

  1. T. O’Callaghan, “The prevention agenda,” Nature 247(7339), S2–S4 (2011).

    Article  Google Scholar 

  2. I. S. Guk, S. G. Kononenko, and F. A. Peev, “On possibilities of production of medical isotope 99mTc in Ukraine,” Visn. Khark. Univ., Ser. Fiz. “Yadra, Chastynky, Polya” 3(47), No. 916, 117–126 (2010).

    Google Scholar 

  3. E. B. Levichev, Feasibility Study of Construction of Proton and Carbon Complex for Cancer Therapy in Khanty-Mansiysk, Part 1: Review of application of proton and ion therapy (Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 2008) [in Russian].

    Google Scholar 

  4. A. F. Tsyb, S. E. Ul’yanenko, and Yu. S. Mardynskii, Neutrons for treatment of malignant neoplasms (BIST, Obninsk, 2003) [in Russian].

    Google Scholar 

  5. R. Soukhami and Dzh. Tobaias, Cancer and its treatment (BINOM, Moscow, 2009) [in Russian].

    Google Scholar 

  6. A. P. Chernyaev, “Nuclear physics-based technologies in medicine,” Phys. Part. Nucl. 43(2), 262–272 (2012).

    Article  Google Scholar 

  7. V. Yu. Baranov, Isotopes (Fizmatlit, Moscow, 2005) [in Russian].

    Google Scholar 

  8. Yu. S. Kudryavtsev and G. A. Feofilov, “Hadron therapy of tumor diseases in the world, Europe, Russia, and Saint-Petersburg,” Medtekh. Medizdeliya 5(34), 29–35 (2006).

    Google Scholar 

  9. D. T. L. Jones, “Fast neutron therapy,” IRPS Bull. 15(2), 1–5 (2001).

    Google Scholar 

  10. M. Catterall and D. Bewley, Fast Neutrons in the Treatment of Cancer (Academic, London, 1979).

    Google Scholar 

  11. L. I. Musabaeva, V. A. Lisin, Zh. A. Startseva, O. V. Gribova, V. V. Velikaya, and A. A. Mel’nikova, “Neutron therapy using U-120 cyclotron. On 30 years of application of neutron therapy: review of the results of the research,” Med. Radiol. Radiats. Bezop. 58(2), 53–61 (2013).

    Google Scholar 

  12. G. I. Borisov, “Theoretical and experimental physical methods of neutron-capture therapy,” Phys. Part. Nucl. 42(5), 713–781 (2011).

    Article  Google Scholar 

  13. F. Rolf, J. A. Coderre, M. G. H. Vicente, and T. E. Blue, “Boron neutron capture therapy of cancer: current status and future prospects,” Clin. Cancer Res. 11(11), 3987–4002 (2005).

    Article  Google Scholar 

  14. J. Gueulette, H. G. Menzel, P. Pihet, and A. Wambersie, Specification of Radiation Quality in Fast Neutron Therapy: Microdosimetric and Radiobiological Approach in Fast Neutrons and High-LET Particles in Cancer Therapy, Ed. by R. Engenhart-Cabillic and A. Wambersie, 1st ed. (Springer-Verlag, Berlin, 1998).

  15. O. V. Savchenko, “40 years of proton therapy using synchrocyclotron and phasotron of the Laboratory of Nuclear Problems of the Joint Institute of Nuclear Research,” Med. Fiz., Nos. 3–4, 2, 60–67 (2007), 53 (2007), 110–120 (2008).

    Google Scholar 

  16. J. M. Cosset, M. Maher, and J. L. Habrand, “New particles in radiotherapy: an introduction,” Radiat. Environ. Biophys. 34, 37–39 (1995).

    Article  Google Scholar 

  17. I. A. Gulidov, Yu. S. Mardynskii, B. M. Vtyurin, A. S. Sysoev, V. S. Medvedev, and S. A. Maksimov, “Fast neutrons of a reactor combined with gammaneutron therapy of patients with cancer of organs of oral cavity and oropharynx,” Ross. Onkol. Zh., No. 6, 4–7 (2000).

    Google Scholar 

  18. M. A. Lone, C. B. Bigham, J. S. Fraser, H. R. Shineider, T. K. Alexander, A. J. Ferguson, and A. B. McDonald, “Thick target neutron yields and spectral distributions from 7Li(dp,n) and 9Be(dp,n) reactions,” Nucl. Instrum. Methods Phys. Res. 143, 331–344 (1977).

    Article  ADS  Google Scholar 

  19. S. Yu. Taskaev, “Accelerator conception of neutron capture therapy. 1. Accelerators (review),” Preprint No. 2011-15, IYaF (Inst. of Nuclear Physics, Novosibirsk, 2011).

    Google Scholar 

  20. A. V. Vazhenin, G. N. Rykovanov, G. V. Mokichev, E. Yu. Kandakova, Z. Z. Munasipov, A. I. Stepanova, and D. N. Astaf’ev, “Distant results of combined photon-neutron therapy of malignant tumors of head and neck in the Ural Center for Neutron Therapy,” Sib. Onkol. Zh. 4(24), 44–49(2007).

  21. V. Skorkin, S. Akulinichev, and A. Andreev, “The high-current deuteron accelerator for the neutron therapy,” in Proceedings of RuPac-2010, Protvino, Russia, 2010, pp. 399–401.

  22. B. F. Bayanov, V. P. Belov, and S. Yu. Taskaev, “Neutron-generating target for neutron-capture therapy,” Preprint No. 2005-4, IYaF (Inst. of Nuclear Physics, Novosibirsk, 2005).

    Google Scholar 

  23. A. S. Kuznetsov, G. N. Malyshkin, A. N. Makarov, I. N. Sorokin, I. S. Sulyaev, and S. Yu. Taskaev, “First experiments on neutron detection on the accelerator-based source for boron neutron capture therapy,” Tech. Phys. Lett. 53(8), 346–348 (2009).

    Article  ADS  Google Scholar 

  24. H. Ensslin, Passive Nondestructive Assay of Nuclear Materials, Ed. by D. Reilly et al. (USA, 1991), p. 700.

  25. L. I. Musabaeva and V. A. Lisin, “20 years of neutron therapy,” Sib. Onkol. Zh. 2–3(10–11), 70–74 (2004).

    Google Scholar 

  26. L. Koester, F. M. Wagner, W. Waschkowski, P. Maier, G. Pfister, R. Senekowitsch, S. Mollenstadt, H. Kriegel, G. Ries, P. Kneschaurek, and A. Breit, “Physical, Biological and Clinical Aspects of the Fission Neutron Physics at the Munich Research Reactor FRM,” in Proceedings of the International Conference on Neutron Physics, Kiev, 14–18 September, 1987, Ed. by B.D. Kuzminov (ZNIatominform, Moscow, 1988), Vol. 4, pp. 198–204.

    Google Scholar 

  27. A. A. Vorob’ev, E. M. Ivanov, A. G. Krivshich, G. A. Ryabov, V. M. Samsonov, D. M. Seliverstov, Yu. N. Gavrish, V. G. Mudrolyubov, A. P. Strokach, V. A. Vostrikov, E. B. Levichev, Yu. A. Tikhonov, V. M. Vinogradov, S. V. Gerasimov, A. M. Granov, R. A. Shalek, and N. N. Yalynych, “Proton therapy center of the Petersburg Institute of Nuclear Physics,” Vopr. At. Nauki Tekh., Ser. Yad.-Fiz. Issled. 4(80), No. 59, 146–150 (2012).

    Google Scholar 

  28. P. V. Bogdanov, I. N. Vasil’chenko, Yu. N. Gavrish, A. V. Galchuk, S. V. Grigorenko, A. N. Kuzhlev, Yu.D. Men’shov, V. G. Mudrolyubov, V. I. Ponomarenko, and A. P. Strokach, “Modern compact NIIEFA cyclotrons for nuclear medicine,” Vopr. At. Nauki Tekh., Ser. Yad.-Fiz. Issled. 4(80), No. 59, 143–146 (2012).

    Google Scholar 

  29. Yu. Amano, “Hybrid schemes of vizualization SPECT/CT and PET/CT,” in Proceedings of the 54th IAEA General Conference, Nuclear Technology Review 2010, GC(54)/INF/3, 2010, pp. 31–32.

  30. S. I. Miyatake, S. Kawabata, Y. Kajimoto, K. Yokoyama, A. Doi, K. Iida, T. Kuroiwa, Y. Imahori, M. Kirihata, Y. Sakurai, A. Maruhashi, S. I. Masunaga, K. Nagata, M. Suzuki, and K. Ono, “Clinical results of BNCT for malignant gliomas using BSH and BRA simultaneously,” in Proceedings of the 12th ICNCT, Japan, 2006, pp. 31–36.

  31. Yu. Amano, “Achievements in application of methods of radiation oncology,” in Proceedings of the 55th IAEA General Conference, Nuclear Technology Review 2011, GC(55)/INF/5, 2011, pp. 38–39.

  32. O. K. Harling, K. J. Riley, P. J. Binns, H. Patel, and J. A. Coderre, “The MIT user center for neutron capture therapy research,” Radiat. Res. 164, 221–229 (2005).

    Article  Google Scholar 

  33. S. V. Kanaev, M. V. Elizarova, M. F. Vorogushin, A. A. Budtov, and V. A. Shishov, “The problem of the shift to modern technologies of radiation therapy in Russian clinics,” Med. Fiz., No. 4, 17–28 (2010).

    Google Scholar 

  34. G. L. Locher, “Biological effects and therapeutic possibilities of neutrons,” Am. J. Roentgenol. 36, 1–13 (1936).

    Google Scholar 

  35. I. B. Sivaev and V. I. Bregadze, “Boron neutron capture therapy of cancer. The clinical aspect,” Ross. Khim. Zh. 48(4), 109–125 (2004).

    Google Scholar 

  36. H. Hatanaka and Y. Nakagava, “Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy,” Int. J. Radiat. Oncol. Biol. Phys. 28, 1061–1066 (1994).

    Article  Google Scholar 

  37. Y. Mishima, “Selective thermal neutron capture therapy of cancer cells using their specific metabolic activities-melanomas prototype,” in Cancer Neutron-Capture Therapy, Ed. by Y. Mishima (Plenum, New York, 1996), pp. 1–26.

    Chapter  Google Scholar 

  38. V. F. Khokhlov, K. N. Zaitsev, and V. I. Kvasov, “Development of radiation technology of treatment of malignant tumors based on neutron capture therapy,” Inzh. Fiz., 1, 52–55 (2000).

    Google Scholar 

  39. V. D. Razumenko, “Boron neutron capture therapy of brain tumors,” Ukr. Neirokhir. Zh., 3, 4–12 (2001).

    Google Scholar 

  40. K. J. Reley, P. J. Binns, O. K. Harling, and W. S. Kiger, “The international dosymetry exchange for BNCT: a basis for pooling and collectively analyzing clinical results,” in Proceedings of 12th international congress on BNCT, Japan, 2006.

  41. I. Kato, K. Ono, Y. Sakurai, M. Ohmae, A. Kamida, Y. Fujita, S. Obayashi, A. Mamhashi, Y. Imahori, M. Kirihata, M. Nakazawa, and Y. Yura, “Boron neutron capture therapy for recurrent head and neck malignancies,” in Proceedings of the 12th ICNCT, Japan, 2006, pp. 1–4.

  42. J. K. Kim and K.-O. Kim, “Current research on accelerator-based boron neutron capture therapy in Korea,” Nucl. Engin. Tech. 41(4), 531–544 (2009).

    Article  Google Scholar 

  43. Yu. N. Koblik, G. A. Abdullaeva, G. A. Kalabdulaev, A. A. Kim, G. Dzhuraeva, K. Belasarov, Zh. N. Kakhkharov, F. D. Kakhkharova, D. T. Rakhmatullaeva, F. S. Islamov, O. A. Agzamov, and I. R. Mavlyanov, “The channel of epithermal neutrons for medical and biological research using the atomic reactor of the Institute of Nuclear Physics of Academy of Sciences of the Republic of Uzbekistan,” Med. Fiz., 3, 31–39 (2011).

    Google Scholar 

  44. R. G. Zamenhof, B. W. Murray, G. L. Brownell, G. R. Wellum, and E. I. Tolpin, “Boron neutron capture therapy for the treatment of cerebral gliomas. Theoretical evaluation of the efficiency of various neutron beams,” Med. Phys. 2, 47–60 (1975).

    Article  Google Scholar 

  45. Yu. A. Kurachenko, Yu. A. Kazanskii, and E. S. Matusevich, “The quality criteria of neutron beams for radiation therapy,” Izv. Vyssh. Uchebn. Zaved., Yad. Energ., 1, 139–149 (2008).

    Google Scholar 

  46. S. S. Arzumanov, L. N. Bondarenko, V. A. Zagryadskii, D. V. Markovskii, V. I. Morozov, A. N. Strepetov, and D. Yu. Chuvilin, “Neutron capture therapy by ultracold neutrons,” At. Energ. 109(1), 19–28 (2010).

    Article  Google Scholar 

  47. Yu. A. Kurachenko, Yu. A. Kazanskii, A. V. Levchenko, and E. S. Matusevich, “Extraction of neutron beams and protection of the Mars medical reactor,” Izv. Vyssh. Uchebn. Zaved., Yad. Energ., No. 4, 36–48 (2006).

    Google Scholar 

  48. S. F. Proskuryakov, I. V. Semenovskaya, and V. V. Uzhvanova, “Sources of cold neutrons in the world,” At. Tekh. Rubezhom, 4, 17–32 (2011).

    Google Scholar 

  49. Yu. A. Kurachenko, Yu. A. Kazanskii, and E. S. Matusevich, “Subcritical systems for neutron capture therapy,” Izv. Vyssh. Uchebn. Zaved., Yad. Energ., 3, 47–56 (2008).

    Google Scholar 

  50. N. I. Aizatskii, B. V. Borts, A. N. Vodin, P. A. Demchenko, Yu. A. Zelinskii, I. M. Karnaukhov, V. A. Kushnir, V. V. Mitrochenko, A. O. Mytsikov, I. M. Neklyudov, S. N. Oleinik, F. A. Peev, G. D. Pugachev, S. A. Soldatov, I. V. Ushakov, I. Gokhar, I. Bol’shinskii, Ya. L. Chi, S. L. Pei, S. Kh. Vong, and V. B. Liu, “The neutron source of the National Science Center Kharkov Institute of Physics and Technology,” Vopr. At. Nauki Tekh., Ser. Yad.-Fiz. Issled., 58, No. 3(79), 3–9 (2012).

    Google Scholar 

  51. Yu. A. Kurachenko, N. K. Voznesenskii, A. A. Goverdovskii, and V. I. Rachkov, “New intense source of neutrons for medical applications,” Med. Fiz., 2, 29–37 (2012).

    Google Scholar 

  52. I. M. Lebedenko, O. V. Staroverov, Yu. V. Zhurov, V. V. Vodyanik, R. A. Gutnik, I. P. Yazhgunovich, N. A. Antipina, P. V. Kazantsev, K. P. Drozdov, and S. A. Tsar’kov, “Electron accelerators of the SL75-5-MT series with an energy of photon radiation of 6 MeV. Dosimetric, clinical, and operational characteristics,” Med. Fiz., 1, 15–20 (2009).

    Google Scholar 

  53. R. R. Wilson, “Radiological use of fast protons,” Radiology 47, 487–491 (1946).

    Article  Google Scholar 

  54. E. M. Syresin, “Accelerator equipment and its application in medidicne,” in Proceedings of the International Conference ISMART-2008, Khar’kov, Ukraine, 2008; E. M. Syresin “Tendencies in the development of accelerator equipment for hadron therapy,” in Proceedings of the International Conference ISMART-2012, Dubna, Russia, 2012.

  55. P. V. Bogdanov, Yu. N. Gavrish, A. V. Galchuk, S. V. Grigorenko, V. I. Grigor’ev, Yu. D. Men’shov, V. G. Mudrolyubov, V. I. Ponomarenko, A. P. Strokach, S. S. Tsygankov, S. A. Artamonov, E. M. Ivanov, G. F. Mikheev, G. A. Ryabov, and V. M. Samsonov, “Main technical characteristics of the Ts-80 cyclotron complex,” Vopr. At. Nauki Tekh., Ser. Yad.-Fiz. Issled. 3(79), No. 58, 10–18 (2012).

    Google Scholar 

  56. E. M. Syresin, V. A. Mikhailov, A. V. Tuzikov, N. N. Agapov, E. D. Donets, E. E. Donets, A. V. Eliseev, V. N. Karpinskii, A. D. Kovalenko, A. I. Malakhov, I. N. Meshkov, A. G. Ol’shevskii, G. V. Trubnikov, G. G. Khadzhibagiyan, G. D. Shirkov, and S. G. Shirkov, “Superconducting synchrotron project for hadron therapy,” Phys. Part. Nucl. Lett. 9(2), 202–212 (2012).

    Article  Google Scholar 

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Correspondence to E. L. Kuplennikov.

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Original Russian Text © A.N. Dovbnya, E.L. Kuplennikov, S.S. Kandybey, V.V. Krasiljnikov, 2014, published in Fizika Elementarnykh Chastits i Atomnogo Yadra, 2014, Vol. 45, No. 5.

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Dovbnya, A.N., Kuplennikov, E.L., Kandybey, S.S. et al. Neutrons against cancer. Phys. Part. Nuclei 45, 972–990 (2014). https://doi.org/10.1134/S1063779614050049

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