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Three-dimensional organization of three-domain copper oxidases: A review

  • Structure of Macromolecular Compounds
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Abstract

“Blue” copper-containing proteins are multidomain proteins that utilize a unique redox property of copper ions. Among other blue multicopper oxidases, three-domain oxidases belong to the group of proteins that exhibit a wide variety of compositions in amino acid sequences, functions, and occurrences in organisms. This paper presents a review of the data obtained from X-ray diffraction investigations of the three-dimensional structures of three-domain multicopper oxidases, such as the ascorbate oxidase catalyzing oxidation of ascorbate to dehydroascorbate and its three derivatives; the multicopper oxidase CueO (the laccase homologue); the laccases isolated from the basidiomycetes Coprinus cinereus, Trametes versicolor, Coriolus zonatus, Cerrena maxima, and Rigidoporus lignosus and the ascomycete Melanocarpus albomyces; and the bacterial laccases CotA from the endospore coats of Bacillus subtilis. A comparison of the molecular structures of the laccases of different origins demonstrates that, structurally, these objects are highly conservative. This obviously indicates that the catalytic activity of the enzymes under consideration is characterized by similar mechanisms.

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Authors and Affiliations

  1. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Leninskiĭ pr. 59, Moscow, 119333, Russia

    N. E. Zhukhlistova, Yu. N. Zhukova, A. V. Lyashenko & A. M. Mikhaĭlov

  2. Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9ST, UK

    V. N. Zaĭtsev

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  1. N. E. Zhukhlistova
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  2. Yu. N. Zhukova
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  3. A. V. Lyashenko
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  4. V. N. Zaĭtsev
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  5. A. M. Mikhaĭlov
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Correspondence to N. E. Zhukhlistova.

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Dedicated to Boris Konstatinovich Vaĭnshteĭn

Original Russian Text © N.E. Zhukhlistova, Yu.N. Zhukova, A.V. Lyashenko, V.N. Zaĭtsev, A. M. Mikhaĭlov, 2008, published in Kristallografiya, 2008, Vol. 53, No. 1, pp. 92–110.

Translated by O. Borovik-Romanova

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Zhukhlistova, N.E., Zhukova, Y.N., Lyashenko, A.V. et al. Three-dimensional organization of three-domain copper oxidases: A review. Crystallogr. Rep. 53, 92–109 (2008). https://doi.org/10.1134/S1063774508010124

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