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RETRACTED ARTICLE: Transient Receptor Potential (TRP) Family of Channel Proteins

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This article was retracted on 01 February 2023

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Abstract

Proteins with a transient receptor potential (TRP) function in the cell membrane as Ca2+-permeable nonselective cation channels. TRP channels play a critical role in the functioning of sensory systems: visual, gustatory, olfactory, auditory, haptic, thermoregulatory, and osmoregulatory. Some members of this superfamily play an important role in the control of growth, differentiation, proliferation, cell polarization, and apoptosis. TRP channels exhibit more diverse activation and selectivity mechanisms than any other group of ion channels—one TRP channel can be activated through multiple mechanisms. However, the TRP family proteins have in common that they play a decisive role in the perception of all major classes of external stimuli and are capable of defining the local changes in the internal environment. The explosion of interest in TRP channels over the past two decades has led to a radical restructuring of the family. The review is devoted to the description of channel proteins receptors of the TRP family, the history of their study, and classification.

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Funding

The work was supported by the Russian Foundation for Basic Research (RFBR), grant no. 20-04-00272а and performed within the framework of the Russian Federation Government Assignment no. 0088-2021-0007 “Molecular Genetic Mechanisms of Regulation of Cellular Differentiation and Morphogenesis.”

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  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    E. E. Kuvaeva, I. B. Mertsalov & O. B. Simonova

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  1. E. E. Kuvaeva
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  2. I. B. Mertsalov
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  3. O. B. Simonova
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Contributions

E.E. Kuvaeva conducted an analysis of world literature and participated in writing the main text of the article. I.B. Mertsalov participated in the editing and discussion of the text of the article. O.B. Simonova initiated the writing of the review and edited the text.

Corresponding author

Correspondence to O. B. Simonova.

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The authors declare that they have no conflicts of interest.

This paper does not contain information on any studies involving humans or animals performed by the authors.

Additional information

Translated by E. Tolkunova

This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1134/S1062360423330019"

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Kuvaeva, E.E., Mertsalov, I.B. & Simonova, O.B. RETRACTED ARTICLE: Transient Receptor Potential (TRP) Family of Channel Proteins. Russ J Dev Biol 53, 309–320 (2022). https://doi.org/10.1134/S1062360422050046

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  • DOI: https://doi.org/10.1134/S1062360422050046

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