Abstract
Neurotransmitters (including serotonin and acetylcholine) perform a number of prenervous functions in early sea urchin development. To detect the particular receptor components involved in these processes, we carried out a database search and nucleotide sequences homologous to serotonin receptor type 4, and the α6- and α10-subunits of nicotinic acetylcholine receptor were found among EST-clones from early Paracentrotus lividus embryos. Expression of these transcripts during early development was demonstrated using RT-PCR. These results are the first molecular biology evidence of serotonin and acetylcholine receptor expression in sea urchin early embryogenesis.
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Original Russian Text © D.A. Nikishin, M.N. Semenova, Yu.B. Shmukler, 2012, published in Ontogenez, 2012, Vol. 43, No. 3, pp. 212–216.
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Nikishin, D.A., Semenova, M.N. & Shmukler, Y.B. Expression of transmitter receptor genes in early development of sea urchin Paracentrotus lividus . Russ J Dev Biol 43, 181–184 (2012). https://doi.org/10.1134/S1062360412030058
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DOI: https://doi.org/10.1134/S1062360412030058