Abstract
The effects of docosahexaenoyl dopamine and docosahexaenoic acid on the regeneration of hydra gastric and basal fragments are studied. Docosahexaenoyl dopamine induced morphogenetic abnormalities such as single ectopic tentacles in the gastric region and projections in the gastric and basal regions. Docosahexaenoic acid had no effect on the morphogenesis except for a mild slowing of the regeneration rate. Since no hydrolysis of docosahexaenoyl dopamine was detected in hydra extract, it was assumed that the morphogenetic effect could be associated with the dopamine component of this complex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Akimov, M.G., Gretskaya, K.V., Shevchenko, V.P., et al., New Aspects of Biosynthesis and Metabolism of N-Acyldopamines in Rat Tissues, Bioorg. Khim., 2007, vol. 33, pp. 648–652.
Bezuglov, V.V., Gretskaya, N.M., Blazhenova, E.L., et al., From Acyl Amino Acids to N-Acylpeptides, Bioorg. Khim., 2006, vol. 32, pp. 258–267.
Bezuglov, V.V., Manevich, E.M., Archakov, A.V., et al., Artificially Functionalized Polyenoic Fatty Acids—New Lipid Bioregulators, Bioorg. Khim., 1997, vol. 23, pp. 211–220.
Buznikov, G.A. and Bezuglov, V.V., Polyenic Acid 5-Hydroxytryptamides and 3-Hydroxytyramides as Tools for Studying of the Prenervous Biogenic Monoamine Functions, Ros. Fiziol. Zh. im. I.M. Sechenova, 2000, vol. 86, no. 9, pp. 1093–1108.
Di Marzo, V., Gianfrani, C., de Petrocellis, L., et al., Polyunsaturated-Fatty-Acid Oxidation in Hydra: Regioselectivity, Substrate-Dependent Enantioselectivity and Possible Biological Role, Biochem. J., 1994, vol. 300(Pt 2). P. 501–507.
Di Marzo, V., de Petrocellis, L., Gianfrani, C., et al., Biosynthesis, Structure and Biological Activity of Hydroxyeicosatetraenoic Acids in Hydra vulgaris, Biochem. J., 1993, vol. 295.
Folch, J., Lees, M., Stanley, G.S., et al., A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues, J. Biol. Chem., 1957, vol. 226, no. 1, pp. 497–509.
Leitz, T., Muller, W., De Petrocellis, L., et al., Enantiospecific Syntesis of Bioactive Hydroxyeicosatetraenoic Acids (HETEs) in Hydra magnipapillata, Biochem. Biophys. Acta, 1994, vol. 1213, no. 2, pp. 215–223.
Markova, L.N., Ostroumova, T.V., Akimov, M.G., et al., N-Arachidonoyl Dopamine is a Possible Factor of the Rate of Tentacle Formation in Freshwater Hydra, Ontogenez, 2008, vol. 39, no. 5, pp. 66–71.
Markova, L.N., Ostroumova, T.V., and Bezuglov, V.V., Effects of N-Arachidonoyl Dopamine, Haloperidol, and Their Mixtures on Regeneration of Freshwater Hydra attenuata, Ontogenez, 2004, vol. 35, no. 5, pp. 367–374.
Muller, W.A., Leitz, T., Stephan, M., et al., Arachidonic Acid and Control of Body Pattern in Hydra, Roux’s. Arch. Devel. Biol., 1993, vol. 202, pp. 70–76.
Ostroumova, T.V. and Markova, L.N., Effect of Inhibitors of Synthesis of Dopamine and Its Antagonists on Hydra attenuate Regeneration, Ros. Fiziol. Zh. im. I.M. Sechenova, 2000, vol. 86, no. 10, pp. 1246–1254.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.V. Ostroumova, L.N. Markova, M.G. Akimov, N.M. Gretskaya, V.V. Bezuglov, 2010, published in Ontogenez, 2010, Vol. 41, No. 3, pp. 199–203.
Rights and permissions
About this article
Cite this article
Ostroumova, T.V., Markova, L.N., Akimov, M.G. et al. Docosahexaenoyl dopamine in freshwater hydra: Effects on regeneration and metabolic changes. Russ J Dev Biol 41, 164–167 (2010). https://doi.org/10.1134/S1062360410030045
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1062360410030045