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Investigation of the Radioprotective Efficiency of Condensation Products of Thiol-Containing Hydrazides with Mono- and Disaccharides

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Abstract

In experiments in mice, the radioprotective efficacy of sugar-containing compounds was studied based on the condensation products of thioglycolic (TGH) and thiosalicylic (TSH) hydrazides with a series of natural aldoses: the monosaccharides D-glucose (Glс) and D-galactose (Gal) and the disaccharides D‑lactose (Lac) and D-maltose (Mal). It was shown that the use of Glc-TGH and Mal-TSH preparations increases the survival rate of deadly irradiated animals by 25% when administered 1 h before irradiation and by 40% when administered 24 h before irradiation. It is assumed that the leading role in the radioprotective activity of the drugs is played by the protection of the hematopoietic stem cells of the test animals.

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REFERENCES

  1. García, I., Gallo, J., Marradi, M., et al., Glyconanoparticles: new nanomaterials for biological application, in Engineered Carbohydrate-Based Materials for Biomedical Applications: Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels, Narain, R., Ed., New Jersey: Wiley, 2011, ch. 2, pp. 213–250.

    Google Scholar 

  2. Fedotcheva, T.A., Starostin, K.M., and Shimanovskii, N.L., Prospects for using gold, silver, and iron oxide nanoparticles for increasing the efficacy of chemotherapy, Pharm. Chem. J., 2015, vol. 49, no. 4, pp. 220–230. https://doi.org/10.1007/s11094-015-1260-6

    Article  CAS  Google Scholar 

  3. Bhattarai, J.K., Neupane, D., Mikhaylov, V., et al., Self-assembled monolayers of carbohydrate derivatives on gold surfaces, in Carbohydrate, Caliskan, M., Kavakli, I.H., and Oz, G.C., Eds., InTech, 2017, ch. 4, pp. 63–97. https://doi.org/10.5772/66194

    Book  Google Scholar 

  4. Haume, K., Rosa, S., Grellet, S., et al., Gold nanoparticles for cancer radiotherapy: a review, Cancer Nano, 2016, vol. 7/8, pp. e1–20. https://doi.org/10.1186/s12645-016-0021-x

    Article  CAS  Google Scholar 

  5. Yang, C., Bromma, K., Di Ciano-Oliveira, C., et al., Gold nanoparticle mediated combined cancer therapy, Cancer Nano, 2018, vol. 9/4, pp. e1–14. https://doi.org/10.1186/s12645-018-0039-3

    Article  CAS  Google Scholar 

  6. Johnke, R.M., Sattler, J.A., and Allison, R.R., Radioprotective agents for radiation therapy: future trends, Future Oncol., 2014, vol. 10, no. 15, pp. 2345–2357. https://doi.org/10.2217/fon.14.175

    Article  CAS  PubMed  Google Scholar 

  7. Ershov, A.Y., Vasil’eva, M.Y., Lagoda, I.V., et al., Condensation products of D-ribose with thiol-containing hydrazides and gold glyconanoparticles thereof, Russ. J. Gen. Chem., 2018, vol. 88, no. 1, pp. 103–108. https://doi.org/10.1134/S1070363218010164

    Article  CAS  Google Scholar 

  8. Vasil’eva, M.Y., Ershov, A.Y., Baigil’din, V.A., et al., Synthesis of silver glyconanoparticles based on 3-thiopropionylhydrazones of mono- and disaccharides, Russ. J. Gen. Chem., 2018, vol. 88, no. 1, pp. 109–113. https://doi.org/10.1134/S1070363218010176

    Article  Google Scholar 

  9. Ershov, A.Y., Vasil’eva, M.Y., Lagoda, I.V., et al., Structure of the condensation products of D-lactose and d-maltose with SH-containing carboxylic acid hydrazides, Russ. J. Gen. Chem., 2018, vol. 88, no. 6, pp. 1199–1204. https://doi.org/10.1134/S1070363218060245

    Article  CAS  Google Scholar 

  10. Vasil’eva, M.Y., Ershov, A.Y., Baigil’din, V.A., et al., Synthesis of gold glyconanoparticles based on the condensation products of D-lactose and D-maltose with SH-containing hydrazides, Russ. J. Gen. Chem., 2018, vol. 88, no. 6, pp. 1205–1209. https://doi.org/10.1134/S1070363218060257

    Article  Google Scholar 

  11. Ershov, A.Y., Martynenkov, A.A., Lagoda, I.V., et al., Synthesis of 4-[ω-(mercaptoalkyl)oxy]benzoylhydrazones of mono- and disaccharides as potential glycoligands of noble metal nanoparticles, Russ. J. Gen. Chem., 2019, vol. 89, no. 2, pp. 292–299. https://doi.org/10.1134/S1070363219020208

    Article  CAS  Google Scholar 

  12. Ershov, A.Y., Vasil’eva, M.Y., Levit, M.L., et al., Synthesis of gold glyconanoparticles based on thiol-containing D-hexose acylhydrazones and their modification by thiolated poly(2-deoxy-2-methacryloylamino-D-glucose), Russ. J. Gen. Chem., 2019, vol. 89, no. 2, pp. 300–308. https://doi.org/10.1134/S107036321902021X

    Article  CAS  Google Scholar 

  13. Mikhailov, P.P. and Korovkina, E.P., Methodological guidelines for the preclinical study of the radioprotective properties of pharmacological compounds, in Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv (Guidelines for Experimental (Preclinical) Study of New Pharmacological Compounds), Khabriev, R.U., Ed., 2nd ed., Moscow: Meditsina, 2005, pp. 724–429.

  14. Metodicheskie rekomendatsii po voprosam opredeleniya chislennosti krovetvornykh kolonieobrazuyushchikh edinits (KOE) s pomoshch’yu testov ekzogennykh i endogennykh selezenochnykh kolonii (Methodological Guidelines on the Determination of the Number of Hematopoietic Colony-Forming Units (CFU) using Tests of Exogenous and Endogenous Spleen Colonies), Obninsk: MRNTs RAMN, 1975.

  15. Berezovskaya, I.V., Classification of chemicals by parameters of acute toxicity with parenteral routes of administration, Khim.-Farm. Zh., 2003, vol. T. 37, no. 3, pp. 32–34.

  16. Filimonova, M.V. and Filimonov, A.S., Modern problems and prospects for the development and implementation of domestic antiradiation drugs, Radiats. Biol. Radioekol., 2019, vol. 59, no. 2, pp. 127–131.

  17. Singh, V., Newman, V.L., Romaine, P.L., et al., Radiation countermeasure agents: an update (2011–2014), Expert. Opin. Ther., vol. 24, no. 11, pp. 1229–1255.

    Article  Google Scholar 

  18. Potučková, E., Hrušková, K., Bureš, J., et al., Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties, PLoS One, 2014, vol. 9, no. 11. e112059. https://doi.org/10.1371/journal.pone.0112059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Ponka, P., Borova, J., Neuwirt, J., et al., Mobilization of iron from reticulocytes. identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent, FEBS Lett., 1997, vol. 97, no. 2, pp. 317–321. https://doi.org/10.1016/0014-5793(79)80111-8

    Article  Google Scholar 

  20. Caro, A.A., Commissariat, A., Dunn, C., et al., Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells, Biochim. Biophys. Acta, 2015, vol. 1850, no. 11, pp. 2256–2264. https://doi.org/10.1016/j.bbagen.2015.08.005

    Article  CAS  Google Scholar 

  21. Charkoudian, L.K., Pham, D.M., and Franz, K.J., A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation, J. Am. Chem. Soc., 2006, vol. 128, no. 38, pp. 12424–12425. https://doi.org/10.1021/ja064806w

    Article  CAS  PubMed  Google Scholar 

  22. Vladimirov, V.G., Krasilnikov, I.I., and Arapov, O.V., Radioprotektory: struktura i funktsiya (Radioprotectors: Structure and Function), Kiev: Naukova dumka, 1989.

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Authors and Affiliations

  1. State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia

    I. V. Lagoda, E. A. Yakunchikova & I. S. Drachyov

  2. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

    A. N. Grebenyuk

  3. Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia

    A. A. Martynenkov & A. Yu. Ershov

  4. Pavlov Ryazan State Medical University, Ryazan, Russia

    L. Yu. Kuleshova & M. A. Kopanitsa

Authors
  1. I. V. Lagoda
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  2. E. A. Yakunchikova
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  3. I. S. Drachyov
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  4. A. N. Grebenyuk
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  5. A. A. Martynenkov
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  6. L. Yu. Kuleshova
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  7. M. A. Kopanitsa
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  8. A. Yu. Ershov
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Correspondence to I. V. Lagoda.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. During the study, the requirements of regulatory legal acts on the procedure for experimental work using animals, including a humane attitude to them, were met: “Code of Ethics” (1985), including the section “International Recommendations for Biomedical Research Using Animals,” the Helsinki Declaration of the World Medical Association (2000), etc.

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Lagoda, I.V., Yakunchikova, E.A., Drachyov, I.S. et al. Investigation of the Radioprotective Efficiency of Condensation Products of Thiol-Containing Hydrazides with Mono- and Disaccharides. Biol Bull Russ Acad Sci 47, 1680–1685 (2020). https://doi.org/10.1134/S1062359020120043

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  • DOI: https://doi.org/10.1134/S1062359020120043

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