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Physiological Effects of Selank and Its Fragments

  • ANIMAL AND HUMAN PHYSIOLOGY
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Abstract—

The development of Selank based on the natural regulatory peptide tuftsin allowed combining the native bioactivity of the molecule with the design engineering of certain physiological functions. Based on a summary of the experimental and clinical data, a comparative analysis of the structural and functional regularities of the effects of Selank and its fragments was performed. The qualitative and quantitative characteristics of correctional processes (anxiolytic, cognitive, immunostimulatory, anti-ulcer, etc.), triggered by the peptide drug and its analogues, are summarized into a single scheme. It is assumed that the Selank effect on the network of cascade processes of peptides and mediators is carried out through enkephalin, the key player of this system.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, 123182, Moscow, Russia

    S. V. Koroleva & N. F. Mjasoedov

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  1. S. V. Koroleva
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  2. N. F. Mjasoedov
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Correspondence to S. V. Koroleva.

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Translated by D. Novikova

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Koroleva, S.V., Mjasoedov, N.F. Physiological Effects of Selank and Its Fragments. Biol Bull Russ Acad Sci 46, 407–414 (2019). https://doi.org/10.1134/S1062359019040071

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  • DOI: https://doi.org/10.1134/S1062359019040071

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