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The nonspecific metabolic reaction of cells to extreme exposures

  • Biochemistry
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Abstract

This work summarizes the authors’ recent investigations into metabolic changes in blood lymphocytes, cancer cells, and hepatocytes during tumor growth from mice with Ehrlich ascites carcinoma. These results were compared with the metabolic changes in hepatocytes from rats after hyperthermia and in lymphocytes from patients with different diseases. It was shown that the extreme conditions induced metabolic changes that were independent of the cell type or the nature of the extreme factor. These changes characterized the metabolic mechanisms of cell adaptation and disadaptation. The concept of the “nonspecific metabolic reaction” of cells to extreme exposures had been introduced.

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Authors and Affiliations

  1. Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50, Krasnoyarsk, 660036, Russia

    E. V. Inzhevatkin

  2. Federal State Budgetary Scientific Institution, Scientific Research Institute of Medical Problems of the North, ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022, Russia

    A. A. Savchenko

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  1. E. V. Inzhevatkin
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  2. A. A. Savchenko
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Correspondence to E. V. Inzhevatkin.

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Original Russian Text © E.V. Inzhevatkin, A.A. Savchenko, 2016, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2016, No. 1, pp. 6–16.

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Inzhevatkin, E.V., Savchenko, A.A. The nonspecific metabolic reaction of cells to extreme exposures. Biol Bull Russ Acad Sci 43, 2–11 (2016). https://doi.org/10.1134/S1062359016010064

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  • DOI: https://doi.org/10.1134/S1062359016010064

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