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Protective action of glutamate antibodies on increased expression of genes of programmed death of rat brain cells induced by injection of a β-amyloid fragment (25–35)

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Abstract

Glutamate antibodies intranasally administered to Wistar rats at a dose of 300 μg/kg reduced the elevated levels of expression of Aifml, Casp3, and Parp1 genes in the prefrontal cortex and Aifml and Casp3 genes in the hippocampus on the third day after administration of the β-amyloid fragment Aβ25–35 into the Meynert nuclei of the brain. Changes in Aifm1, Bax, Casp3, and Parp1 gene expression were not found in the hypothalamus, and changes in Bax gene expression were not found in the brain structures studied. The discovered features of gene expression in the prefrontal cortex and hippocampus are considered in terms of development of various cell-death programs, which are modulated by glutamate antibodies.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Volokolamskoe sh. 80, Moscow, 125367, Russia

    V. V. Kolobov

  2. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia

    T. V. Davydova & V. G. Fomina

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  1. V. V. Kolobov
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  2. T. V. Davydova
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  3. V. G. Fomina
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Correspondence to V. V. Kolobov.

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Original Russian Text © V.V. Kolobov, T.V. Davydova, V.G. Fomina, 2014, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2014, No. 2, pp. 133–141.

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Kolobov, V.V., Davydova, T.V. & Fomina, V.G. Protective action of glutamate antibodies on increased expression of genes of programmed death of rat brain cells induced by injection of a β-amyloid fragment (25–35). Biol Bull Russ Acad Sci 41, 118–125 (2014). https://doi.org/10.1134/S1062359014020034

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  • DOI: https://doi.org/10.1134/S1062359014020034

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