Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ25-35 in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of the experimental animals in the conditioned passive avoidance paradigm.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 7, pp. 28–30, July, 2010
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Gorbatov, V.Y., Trekova, N.A., Fomina, V.G. et al. Antiamnestic Effects of Antibodies to Glutamate in Experimental Alzheimer’s Disease. Bull Exp Biol Med 150, 23–25 (2010). https://doi.org/10.1007/s10517-010-1058-1
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DOI: https://doi.org/10.1007/s10517-010-1058-1