Abstract
We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation. Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min. At the same time there was increase of anti-thrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity. Dipeptides were found to have the greatest antistress effect. Our results showed that semax had a protective effect against enhanced blood coagulability resulting from repeated immobilization stress.
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Original Russian Text © L.A. Lyapina, M.E. Grigor’eva, L.A. Andreeva, N.F. Myasoedov, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 4, pp. 462–467.
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Lyapina, L.A., Grigor’eva, M.E., Andreeva, L.A. et al. Protective antithrombotic effects of proline-containing peptides under the influence of stress on the animal organism. Biol Bull Russ Acad Sci 37, 392–396 (2010). https://doi.org/10.1134/S1062359010040096
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DOI: https://doi.org/10.1134/S1062359010040096