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Collagen Hydrolysis Products Reduce the Formation of Stress-Induced Ulcers by Regulating Stress-Associated Activation of the Neuroendocrine and Immune Systems

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood. The concentrations of IL-1β in cell culture from regional lymph node of experimental animals returned to normal in 24 and 48 h after the stress. Acetylation of PGP prevents with gastroprotection, but does not abrogate other properties of the peptide.

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Authors and Affiliations

  1. Peoples Friendship University of Russia, Moscow, Russia

    Z. V. Bakaeva, N. V. Ermakova, O. V. Mankaeva, D. S. Sveshnikov, A. E. Severin, A. N. Sinel’nikova, Yu. P. Starshinov, I. V. Radysh, V. I. Torshin & D. A. Frolov

  2. National Medical Research Center of Children’s Health, Ministry of Health of the Russian Federation, Moscow, Russia

    Z. V. Bakaeva

  3. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

    I. G. Kozlov

Authors
  1. Z. V. Bakaeva
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  2. N. V. Ermakova
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  3. O. V. Mankaeva
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  4. D. S. Sveshnikov
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  5. A. E. Severin
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  6. A. N. Sinel’nikova
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  7. Yu. P. Starshinov
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  8. I. V. Radysh
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  9. V. I. Torshin
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  10. D. A. Frolov
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  11. I. G. Kozlov
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Corresponding author

Correspondence to Z. V. Bakaeva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 4, pp. 438-442, April, 2018

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Bakaeva, Z.V., Ermakova, N.V., Mankaeva, O.V. et al. Collagen Hydrolysis Products Reduce the Formation of Stress-Induced Ulcers by Regulating Stress-Associated Activation of the Neuroendocrine and Immune Systems. Bull Exp Biol Med 165, 449–452 (2018). https://doi.org/10.1007/s10517-018-4191-x

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  • DOI: https://doi.org/10.1007/s10517-018-4191-x

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