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Stem cell self-renewal: The role of asymmetric division

  • Cell Biology
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Abstract

Asymmetric division occurs widely in different groups of organisms from single-celled to insects, mammals, and plants. The operation of asymmetrical division may differ widely in different organisms. In multicellular organisms, asymmetrical division is one of the essential features of stem cell biology. The data obtained assume one of the main biological functions of asymmetrical division to be maintenance of cell viability, beginning with stem cells. Cells continuously accumulate toxic inclusions, which are formed by damaged proteins which cannot be degraded by proteasomes. As a result of asymmetric division, these inclusions segregate into one of the daughter cells providing the ability of long-lived proliferation to another cell.

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Authors and Affiliations

  1. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia

    V. V. Terskikh, A. V. Vasil’ev & E. A. Voroteliak

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  1. V. V. Terskikh
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  2. A. V. Vasil’ev
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  3. E. A. Voroteliak
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Correspondence to V. V. Terskikh.

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Original Russian Text © V.V. Terskikh, A.V. Vasil’ev, E.A. Voroteliak, 2009, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2009, No. 5, pp. 509–514.

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Terskikh, V.V., Vasil’ev, A.V. & Voroteliak, E.A. Stem cell self-renewal: The role of asymmetric division. Biol Bull Russ Acad Sci 36, 425–429 (2009). https://doi.org/10.1134/S106235900905001X

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