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Novel Mixed-Mode Adsorbents for HPLC Based on Different Substrates Modified with Eremomycin

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Abstract

New adsorbents based on silica and polystyrene–divinylbenzene (PS–DVB) for hydrophilic interaction liquid chromatography (HILIC) with eremomycin in functional layers were obtained. The chromatographic properties of the new adsorbents were assessed using the Tanaka test for hydrophilic stationary phases and by studying the retention of substances of various classes in HILIC, chiral, and reversed-phase chromatography modes. It was shown that the use of eremomycin to create functional layers leads to an increase in the hydrophilicity of the adsorbents on different types of substrates and ensures the shielding of their charge. Eleven nitrogenous bases, nucleosides with an efficiency of up to 25 000 tp/m, or seven vitamins with an efficiency of up to 40 000 tp/m can be separated on a modified sorbent based on aminopropyl silica, and three different HPLC modes can be implemented on the sorbent with eremomycin based on PS–DVB.

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Funding

This work was supported by the Russian Foundation for Basic Research, project no. 20-03-00909, within the framework of the Development Program of the Interdisciplinary Scientific and Educational School of Moscow University “The Future of the Planet and Global Environmental Changes” using the equipment of the Collective Use Center of Moscow State University “Technologies for obtaining new nanostructured materials and their Comprehensive Research”, acquired by Moscow State University under the program for updating the instrumentation base within the framework of the national project “Science” and within the framework of the Development Program of Moscow State University.

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Authors and Affiliations

  1. Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia

    N. Yu. Chikurova, D. S. Prosuntsova, A. N. Stavrianidi, S. M. Staroverov, I. A. Ananieva, A. D. Smolenkov & A. V. Chernobrovkina

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  1. N. Yu. Chikurova
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  2. D. S. Prosuntsova
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  3. A. N. Stavrianidi
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  4. S. M. Staroverov
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  5. I. A. Ananieva
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  6. A. D. Smolenkov
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  7. A. V. Chernobrovkina
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Correspondence to A. V. Chernobrovkina.

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Translated by V. Kudrinskaya

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Chikurova, N.Y., Prosuntsova, D.S., Stavrianidi, A.N. et al. Novel Mixed-Mode Adsorbents for HPLC Based on Different Substrates Modified with Eremomycin. J Anal Chem 78, 592–604 (2023). https://doi.org/10.1134/S1061934823050039

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  • DOI: https://doi.org/10.1134/S1061934823050039

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