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Determination of novobiocin by a kinetic spectrophotometric method in milk and biological samples

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Abstract

A new, simple, inexpensive, and fast kinetic spectrophotometric method was developed for the determination of trace amounts of antibiotic drug novobiocin sodium over the range of 4‒32 ng/mL. The method is based on the inhibitory effect of novobiocinon the reaction of Amido Black and periodate in the acidic micellar mediums. The reaction was monitored spectrophotometrically by measuring the decrease in absorbance at 627 nm and fixed-time 6 min from initiation of the reaction. The detection limit is 3 ng/mL, and relative standard deviation for 4.8 and 12 ng/mL novobiocin were 0.52 and 0.65%, respectively, for six replicate measurements. The method was applied to the determination of novobiocin in human and dog serum, urine, and milk samples.

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Authors and Affiliations

  1. Department of Chemistry, Majlesi Branch, Islamic Azad University Isfahan, Isfahan, Iran

    Mohsen Keyvanfard & Khadijeh Alizad

  2. Department of Chemistry, Shahreza Branch, Islamic Azad University Isfahan, Isfahan, Iran

    Nazila Najjarian

Authors
  1. Mohsen Keyvanfard
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  2. Khadijeh Alizad
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  3. Nazila Najjarian
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Correspondence to Mohsen Keyvanfard.

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Keyvanfard, M., Alizad, K. & Najjarian, N. Determination of novobiocin by a kinetic spectrophotometric method in milk and biological samples. J Anal Chem 72, 1028–1033 (2017). https://doi.org/10.1134/S1061934817100124

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  • DOI: https://doi.org/10.1134/S1061934817100124

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