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Chromatographic determination of drotaverine hydrochloride and kinetic modeling of the process of its biodestruction in a R. rhodochrous culture liquid

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Abstract

A method has been developed for the determination of drotaverine hydrochloride in a postfermentation medium of the cultivation of actinobacteria by reversed-phase high-performance liquid chromatography. The specificity, linearity, reproducibility, and accuracy of the method have been evaluated. It has been demonstrated that the process of the biological destruction of drotaverine hydrochloride is adequately represented by a first-order kinetic equation with a variable reaction rate constant. Kinetic modeling has shown the possibility of substantially reducing the size and duration of the experiment, as well as of evaluating the time of completion of the process of drotaverine hydrochloride biodestruction.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, ul. Polevaya 2, Perm, 614990, Russia

    Yu. N. Karpenko & E. V. Vikhareva

  2. Perm National Research Polytechnical University, Komsomol’skii pr. 29, Perm, 614990, Russia

    A. A. Selyaninov & A. A. Baranova

  3. Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia

    A. N. Mukhutdinova, M. I. Rychkova & I. B. Ivshina

  4. Perm State National Research University, ul. Bukireva 15, Perm, 614990, Russia

    I. B. Ivshina

Authors
  1. Yu. N. Karpenko
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  2. A. A. Selyaninov
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  3. A. N. Mukhutdinova
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  4. M. I. Rychkova
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  5. A. A. Baranova
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  6. E. V. Vikhareva
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  7. I. B. Ivshina
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Corresponding author

Correspondence to I. B. Ivshina.

Additional information

Original Russian Text © Yu.N. Karpenko, A.A. Selyaninov, A.N. Mukhutdinova, M.I. Rychkova, A.A. Baranova, E.V. Vikhareva, I.B. Ivshina, 2014, published in Zhurnal Analiticheskoi Khimii, 2014, Vol. 69, No. 7, pp. 750–755.

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Karpenko, Y.N., Selyaninov, A.A., Mukhutdinova, A.N. et al. Chromatographic determination of drotaverine hydrochloride and kinetic modeling of the process of its biodestruction in a R. rhodochrous culture liquid. J Anal Chem 69, 681–685 (2014). https://doi.org/10.1134/S1061934814070077

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  • DOI: https://doi.org/10.1134/S1061934814070077

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