Abstract
X-Ray photoelectron spectroscopy hyphenated with selective chemical reactions is used to study the chemical composition of the surface of initial and mechanically activated powdered calcium gluconate as a medicinal preparation and a pure chemical reagent. Specific features of selective chemical reactions between calcium gluconate and hydrazine and trifluoroacetic anhydride are studied. The low yield of reactions of the medicinal preparation is due to the additives present in its composition, which reduce the steric accessibility of the analyzed groups to the labeling reagent. It is shown that the mechanical activation of the medicinal preparation is accompanied by its slight thermal destruction.
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Original Russian Text © A.A. Shakov, S.S. Mikhailova, G.N. Konygin, 2011, published in Zhurnal Analiticheskoi Khimii, 2011, Vol. 66, No. 8, pp. 848–853.
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Shakov, A.A., Mikhailova, S.S. & Konygin, G.N. Study of the surface composition of mechanically activated of calcium gluconate by X-ray photoelectron spectroscopy using selective chemical reactions. J Anal Chem 66, 734–739 (2011). https://doi.org/10.1134/S1061934811080120
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DOI: https://doi.org/10.1134/S1061934811080120