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Synthesis and Properties of Chitosan- and Pectin-Based Hydrogels

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Abstract

Hydrogels have been prepared by mixing chitosan and pectin solutions, as well as solutions of their modified derivatives, in aqueous media at room temperature. The gels are obtained within a time period from several seconds to half an hour or more, depending on the process conditions. The hydrogels are formed due to both the covalent bonding between functional groups and the formation of interpolyelectrolyte complexes via the interaction between ammonium groups of chitosan and carboxylate groups of pectin. Conditions have been determined for the hydrogel formation throughout the solution volume without liquid phase separation. The swelling of lyophilized hydrogels has been studied as depending on the ionic strength and pH of aqueous media. The feasibility of prolonged drug release from the developed polymer matrix has been shown by the example of cytostatics, namely, mitomycin C and cisplatin.

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ACKNOWLEDGMENTS

Spectroscopic and chromatographic analyses were performed using the equipment of the Khimiya Center for Collective Use, Ufa Institute of Chemistry, Ufa Research Center, Russian Academy of Sciences.

Funding

This work was performed within the framework of the Program of Basic Research of the State Academies for 2019–2021, state orders nos. АААА-А20-120012090024-5 and АААА-А20-120012090029-0 .

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    N. N. Sigaeva, R. R. Vil’danova & S. P. Ivanov

  2. Republican Clinical Oncological Didpensary, 450054, Salavat, Russia

    A. V. Sultanbaev

Authors
  1. N. N. Sigaeva
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  2. R. R. Vil’danova
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  3. A. V. Sultanbaev
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  4. S. P. Ivanov
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Correspondence to N. N. Sigaeva.

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The authors declare that they have no conflict of interest.

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Translated by L. Tkachenko

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Sigaeva, N.N., Vil’danova, R.R., Sultanbaev, A.V. et al. Synthesis and Properties of Chitosan- and Pectin-Based Hydrogels. Colloid J 82, 311–323 (2020). https://doi.org/10.1134/S1061933X20030114

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  • DOI: https://doi.org/10.1134/S1061933X20030114

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