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A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

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Abstract

It has been shown that mesoporous nanocontainers from SiO2 may be obtained by the sol–gel synthesis using drug (Miramistin) micelles as a template. The nanocontainers resulting from the combination of the stages of their synthesis and loading are characterized by a very high content of the drug (no less than 0.9 g per 1 g of SiO2). The kinetics of Miramistin desorption from the mesoporous particles into an aqueous medium has been studied under static and quasi-dynamic conditions. The desorption has been shown to rather strongly depend on pH. Possible mechanisms of the desorption process have been discussed.

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119071, Russia

    O. V. Dement’eva, I. N. Senchikhin, M. E. Kartseva, V. A. Ogarev, A. V. Zaitseva & V. M. Rudoy

  2. Department of Chemistry, Moscow State University, Moscow, 119992, Russia

    N. N. Matushkina

Authors
  1. O. V. Dement’eva
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  2. I. N. Senchikhin
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  3. M. E. Kartseva
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  4. V. A. Ogarev
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  5. A. V. Zaitseva
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  6. N. N. Matushkina
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  7. V. M. Rudoy
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Corresponding author

Correspondence to O. V. Dement’eva.

Additional information

Original Russian Text © O.V. Dement’eva, I.N. Senchikhin, M.E. Kartseva, V.A. Ogarev, A.V. Zaitseva, N.N. Matushkina, V.M. Rudoy, 2016, published in Kolloidnyi Zhurnal, 2016, Vol. 78, No. 5, pp. 539–549.

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Dement’eva, O.V., Senchikhin, I.N., Kartseva, M.E. et al. A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template. Colloid J 78, 586–595 (2016). https://doi.org/10.1134/S1061933X16050045

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  • DOI: https://doi.org/10.1134/S1061933X16050045

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