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Inhibition of Ostwald ripening in heptane/water miniemulsions

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Abstract

The Ostwald ripening has been shown to cause the degradation of model low-concentrated heptane/water miniemulsions containing, as the only stabilizer, Tween 80 (Tw), hydroxypropyl cellulose (HPC), a drug (amlodipine (Am) or felodipine (F)), or a promoter of skin permeability (glyceryl monooleate (GMO)). The efficiency of the Ostwald ripening inhibition increases in the following series: Am < Tw < GMO < HPC < F. The analysis of different mechanisms of the Ostwald ripening inhibition by the hydrophilic (Tw, HPC) and lipophilic (Am, F, GMO) surface-active stabilizers has resulted in the preparation of a stable high-concentrated miniemulsion containing F, GMO, HPC, and Tw, this emulsion being promising for pharmaceutical fields of application.

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  1. Department of Chemistry, Moscow State University, Moscow, 119992, Russia

    N. M. Zadymova & G. A. Arshakyan

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  1. N. M. Zadymova
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  2. G. A. Arshakyan
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Original Russian Text © N.M. Zadymova, G.A. Arshakyan, 2014, published in Kolloidnyi Zhurnal, 2014, Vol. 76, No. 1, pp. 28–41.

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Zadymova, N.M., Arshakyan, G.A. Inhibition of Ostwald ripening in heptane/water miniemulsions. Colloid J 76, 25–37 (2014). https://doi.org/10.1134/S1061933X14010165

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