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Major Scenarios of Genetically Regulated Cell Death during Oogenesis in Drosophilamelanogaster

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Abstract

The process of regulated cell death (RCD), as well as proliferation and differentiation, is an important and integral part of the development of any multicellular organism. There are a number of different mechanisms of RCD that can be activated in response to developmental and environmental signals. In this review, we focus on the new insights into the main cellular events and molecular mechanisms characterizing different cell death pathways during oogenesis in Drosophila melanogaster. During Drosophila oogenesis, at least five different stage-specific RCD scenarios are realized, including (1) caspase-dependent death of the germline cells (GCs) in early oogenesis, which is mediated by autophagy; (2) canonical apoptosis, which removes the excess of somatic polar cells at stages 4–5 of oogenesis; (3) RCD of mid-stage egg chambers, which begins with caspase-dependent death of GCs with the participation of autophagy and finishes with their engulfment by the surrounding follicle cells (FCs); (4) non-apoptotic RCD of late-stage nurse cells, initiated and controlled by the surrounding FCs; (5) caspase-independent death of the FCs that have fulfilled their functions through autophagy at the end of stage 14.

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Funding

This study was supported by the budget financing on the state contract no. 0324-2019-0042-C-01.

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Authors and Affiliations

  1. Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    E. U. Bolobolova, N. V. Dorogova & S. A. Fedorova

  2. Novosibirsk National Research State University, 630090, Novosibirsk, Russia

    S. A. Fedorova

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  1. E. U. Bolobolova
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  2. N. V. Dorogova
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  3. S. A. Fedorova
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Correspondence to E. U. Bolobolova or S. A. Fedorova.

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Translated by N. Maleeva

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Bolobolova, E.U., Dorogova, N.V. & Fedorova, S.A. Major Scenarios of Genetically Regulated Cell Death during Oogenesis in Drosophilamelanogaster. Russ J Genet 56, 655–665 (2020). https://doi.org/10.1134/S1022795420060034

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