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Genetic and Genomic Basis of Aggressive Behavior

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Abstract

Genetic and genomic studies of aggressive behavior are of great interest both for clinical medicine, which is related to treatment of patients with various forms of personality and psychiatric disorders, and for forensic purposes, in particular, for prognostication of different types of crime. Moreover, genetic research of aggressive behavior has major importance in connection to social and familial relationships, dealing with relations to children in society and family. Numerous studies have been published in this field. The present review describes studies on the genetic basis of aggressive/antisocial behavior, genome wide associations, and meta-analyses. The problems of genotype–social environment interaction and epigenetic mechanisms of genotype implementation in humans are discussed.

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Notes

  1. GTP-binding proteins.

  2. Channel forming proteins supporting the potential difference existing between the outer and inner sides of the cell membrane.

  3. The coefficient of disagreement (also known as odds ratio or risk ratio). It is used to describe the results of logistic regression and is calculated from a table including the number of observed and predicted values for binary dependent variables in the cells.

  4. GPCR—G protein coupled receptor signaling pathway.

  5. ERK/MAPK—ERK is extracellular signal regulated kinase; MAPK is mitogen-activated protein kinase.

  6. Rho-GTPases—family of cell signaling proteins, subgroup of small GTP hydrolases of Ras superfamily.

  7. Reelin is a protein found in the brain and other tissues and organs in humans and animals; it regulates the migration and positioning of nerve stem cells and contributes to the mechanisms of memory and learning.

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This study was supported by the Program of Union State “DNA Identification.”

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  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia

    A. Yu. Dragovich & S. A. Borinskaya

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Dragovich, A.Y., Borinskaya, S.A. Genetic and Genomic Basis of Aggressive Behavior. Russ J Genet 55, 1445–1459 (2019). https://doi.org/10.1134/S1022795419090059

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