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Antigenotoxic activity of biologically active substances from Inula britannica and Limonium gmelini

  • General Genetics
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Abstract

The antigenotoxic and antioxidant activities of biologically active substances of extracts from Inula britannica L. and Limonium gmelinii (Willd.) Kuntze in E. coli strains MG1655 (pColD-lux), MG1655 (pSoxS-lux), and MG1655 (pKatG-lux) were studied by the bioluminescent test. Plant extracts from I. britannica and L. gmelinii in all used concentrations (0.5, 5.0, 50.0, and 500.0 μg/mL) had no genotoxic or oxidant activity. The extracts statistically significantly reduced the bioluminescence intensity of the pColD-lux, pKatG-lux, and pSoxS-lux sensors (p < 0.05) induced by 4-NQO and dioxidine, hydrogen peroxide, and paraquat, respectively. The activity of the extracts depended on their concentration; the greatest antigenotoxic and antioxidant effects were detected at a concentration of 500.0 μg/mL.

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Authors and Affiliations

  1. Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan

    A. V. Lovinskaya, S. Zh. Kolumbayeva & T. M. Shalakhmetova

  2. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    M. V. Marsova & S. K. Abilev

  3. Department of Genetics, Moscow State University, Moscow, 119991, Russia

    S. K. Abilev

Authors
  1. A. V. Lovinskaya
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  2. S. Zh. Kolumbayeva
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  3. T. M. Shalakhmetova
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  4. M. V. Marsova
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  5. S. K. Abilev
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Correspondence to A. V. Lovinskaya.

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Original Russian Text © A.V. Lovinskaya, S.Zh. Kolumbayeva, T.M. Shalakhmetova, M.V. Marsova, S.K. Abilev, 2017, published in Genetika, 2017, Vol. 53, No. 12, pp. 1393–1401.

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Lovinskaya, A.V., Kolumbayeva, S.Z., Shalakhmetova, T.M. et al. Antigenotoxic activity of biologically active substances from Inula britannica and Limonium gmelini . Russ J Genet 53, 1311–1319 (2017). https://doi.org/10.1134/S1022795417120080

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  • DOI: https://doi.org/10.1134/S1022795417120080

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